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How non-alcoholic fatty liver disease and cirrhosis affect the heart
Liver diseases affect the heart and the vascular system. Cardiovascular complications appear to be a leading cause of death in patients with...
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Unusual coexistence of restrictive heart disease and Kallmann syndrome: a case report
BackgroundKallmann–Morsier syndrome is a rare disease characterized by the association of congenital gonadotropic deficiency and anosmia or hyposmia....
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Cardiac fibroblasts and mechanosensation in heart development, health and disease
The term ‘mechanosensation’ describes the capacity of cells to translate mechanical stimuli into the coordinated regulation of intracellular signals,...
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Right heart failure after left ventricular assist device implantation: a persistent problem
Left ventricular assist device (LVAD) is an option for bridge-to-transplant or destination therapy for patients with end-stage heart failure. Right...
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Salt and Gut Microbiota in Heart Failure
Purpose of ReviewThe role and underlying mechanisms mediated by dietary salt in modulating the gut microbiota and contributing to heart failure (HF)...
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Contemporary Management of Cardiomyopathy and Heart Failure in Pregnancy
Cardiovascular disease is the primary cause of pregnancy-related mortality and morbidity in the United States, and maternal mortality has increased...
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Targeting cardiomyocyte cell cycle regulation in heart failure
Heart failure continues to be a significant global health concern, causing substantial morbidity and mortality. The limited ability of the adult...
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Induced Pluripotent Stem Cell–Based Modeling of Single-Ventricle Congenital Heart Diseases
Purpose of ReviewCongenital heart disease includes a wide variety of structural cardiac defects, the most severe of which are single ventricle...
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Insights into the Inherited Basis of Valvular Heart Disease
Purpose of ReviewIncreases in the availability of genetic data and advances in the tools and methods for their analyses have enabled well-powered...
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Heart Failure-Related Iron Deficiency Anemia Pathophysiology and Laboratory Diagnosis
Purpose of ReviewThe goal of the current review is to give an overview regarding the pathophysiology of iron deficiency in heart failure and how...
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Change of Heart: the Epitranscriptome of Small Non-coding RNAs in Heart Failure
Purpose of ReviewSmall non-coding RNAs regulate gene expression and are highly implicated in heart failure. Recently, an additional level of...
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The value of cardiac sympathetic activity and mechanical dyssynchrony as cardiac resynchronization therapy response predictors: comparison between patients with ischemic and non-ischemic heart failure
BackgroundImpaired cardiac sympathetic activity and mechanical dyssynchrony (MD) are associated with poor prognosis in patients with heart failure...
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Advances in novel devices for the treatment of heart failure
Heart failure (HF) is one of the leading causes of global health impairment. Current drugs are still limited in their effectiveness in the treatment...
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Ischemic Cardiomyopathy and Heart Failure After Acute Myocardial Infarction
Purpose of ReviewIschemic cardiomyopathy refers to systolic left ventricular dysfunction in the setting of obstructive coronary artery disease and...
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Exploring the Mechanistic Link Between Obesity and Heart Failure
Abstract Purpose of ReviewAmong subtypes of cardiovascular disease, obesity has a potent and unique association with heart failure (HF) that is...
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Valvular heart disease and cardiomyopathy: reappraisal of their interplay
Cardiomyopathies and valvular heart diseases are typically considered distinct diagnostic categories with dedicated guidelines for their management....
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Sex differences in heart: from basics to clinics
Sex differences exist in the structure and function of human heart. The patterns of ventricular repolarization in normal electrocardiograms (ECG)...
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Finding New Targets for the Treatment of Heart Failure: Endoplasmic Reticulum Stress and Autophagy
AbstractHeart failure is a progressive disease with an annual mortality rate of about 10% and is the end-stage stage of various heart diseases, which...
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PATHFINDER-CHD: prospective registry on adults with congenital heart disease, abnormal ventricular function, and/or heart failure as a foundation for establishing rehabilitative, prehabilitative, preventive, and health-promoting measures: rationale, aims, design and methods
BackgroundAdults with congenital heart defects (ACHD) globally constitute a notably medically underserved patient population. Despite therapeutic...
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Heart Conditioning and Heterochronic Parabiotic Models as Healthy Strategies
In heterochronic parabiotic model, there is reversion of aging and age-related diseases. Blood or plasma exchange, as well as implementation of young...
