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Estrogen alleviates post-traumatic osteoarthritis progression and decreases p-EGFR levels in female mouse cartilage
ObjectiveTo investigate the effect of estrogen on the progression of post-traumatic osteoarthritis (PTOA) in mice and its possible mechanism.
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miR-124-3p sabotages lncRNA MALAT1 stability to repress chondrocyte pyroptosis and relieve cartilage injury in osteoarthritis
BackgroundOsteoarthritis (OA) is a prevalent inflammatory joint disorder. microRNAs (miRNAs) are increasingly involved in OA.
AimOur study is...
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Inflammatory cytokines and mechanical injury induce post-traumatic osteoarthritis-like changes in a human cartilage-bone-synovium microphysiological system
BackgroundTraumatic knee injuries in humans trigger an immediate increase in synovial fluid levels of inflammatory cytokines that accompany impact...
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Intra-articular injections in sport-active patients with degenerative cartilage lesions or osteoarthritis of the knee: a systematic review
PurposeThe aim of this systematic review was to analyse the available clinical evidence on intra-articular knee injections for the treatment of...
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The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity
Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting a variety of cell types, whose activity and interplay...
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Cartilage lesion size and number of stromal vascular fraction (SVF) cells strongly influenced the SVF implantation outcomes in patients with knee osteoarthritis
PurposeThis study evaluated outcomes in patients with knee osteoarthritis following stromal vascular fraction implantation and assessed the...
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Chondrocyte-derived exosomes promote cartilage calcification in temporomandibular joint osteoarthritis
BackgroundsAbnormal cartilage calcification is one of the pathological changes of temporomandibular joint (TMJ) osteoarthritis (OA). Recent studies...
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Exploring the differences between radiographic joint space width and MRI cartilage thickness changes using data from the IMI-APPROACH cohort
ObjectiveLongitudinal weight-bearing radiographic joint space width (JSW) and non-weight-bearing MRI-based cartilage thickness changes often show...
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Osteophytes mediate the associations between cartilage morphology and changes in knee symptoms in patients with knee osteoarthritis
AimsTo investigate whether the associations between cartilage defects and cartilage volumes with changes in knee symptoms were mediated by...
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Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis
BackgroundOsteoarthritis (OA) is the most common form of arthritis and is characterized by the degradation of articular cartilage and inflammation of...
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LncPVT1 promotes cartilage degradation in diabetic OA mice by downregulating miR-146a and activating TGF-β/SMAD4 signaling
IntroductionTo investigate the role of LncRNA PVT1 (plasmacytoma variant translocation 1) in hyperglycemia-triggered cartilage damage using the...
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Impaired autophagy contributes to the aggravated deterioration of osteoarthritis articular cartilage by peroxisome proliferator-activated receptor α deficiency, associated with decreased ERK and Akt activation
BackgroundAlthough the chondroprotection of peroxisome proliferator-activated receptor α (PPARα) activation against osteoarthritis (OA) has been...
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Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage
IntroductionSelenium (Se) as well as selenoproteins are vital for osteochondral system development. Se deficiency (SeD) has a definite impact on the...
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Concentration of synovial fluid biomarkers on the day of anterior cruciate ligament (ACL)-reconstruction predict size and depth of cartilage lesions on 5-year follow-up
PurposeThe current investigation evaluated the relationship between the synovial fluid cytokine microenvironment at the time of isolated anterior...
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MiR-99a alleviates apoptosis and extracellular matrix degradation in experimentally induced spine osteoarthritis by targeting FZD8
BackgroundOur previous study identified miR-99a as a negative regulator of early chondrogenic differentiation. However, the functional role of...
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Adjacent cartilage tissue structure after successful transplantation: a quantitative MRI study using T2 map** and texture analysis
ObjectivesThe aim of this study was to assess the texture of repair tissue and tissue adjacent to the repair site after matrix-associated chondrocyte...
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Isorhynchophylline alleviates cartilage degeneration in osteoarthritis by activating autophagy of chondrocytes
ContextOsteoarthritis is a common degenerative disease, the cause of it is still unknown, and the treatment mainly focuses on improving symptoms....
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Transcriptional profiling of human cartilage endplate cells identifies novel genes and cell clusters underlying degenerated and non-degenerated phenotypes
BackgroundLow back pain is a leading cause of disability worldwide and is frequently attributed to intervertebral disc (IVD) degeneration. Though the...
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Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage
IntroductionA disintegrin and metalloproteinase 17 (Adam17), also known as TNFα-converting enzyme (Tace), is a membrane-anchored protein involved in...
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Expression of CILP-2 and DDR2 and ultrastructural changes in the articular cartilage of patients with knee osteoarthritis undergoing total knee arthroplasty: a pilot morphological study
The aim of the study was to correlate the immunohistochemical expression of cartilage intermediate layer protein 2 (CILP-2) and discoidin domain...
