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Sex Differences in the Risk of Cutaneous Adverse Drug Reactions Induced by Antiseizure Medications: A Systematic Review and Meta-analysis
BackgroundCutaneous adverse drug reactions (cADRs) are one of the most common, severe, and life-threatening types of adverse reactions following...
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Tardive Dyskinesia with Antipsychotic Medication in Children and Adolescents: A Systematic Literature Review
BackgroundTardive dyskinesia (TD) is a persisting, and potentially irreversible, movement disorder associated with treatment with dopamine receptor...
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Effect of Enzyme-Inducing Antiseizure Medications on the Risk of Sub-Therapeutic Concentrations of Direct Oral Anticoagulants: A Retrospective Cohort Study
BackgroundStroke and thromboembolic events occurring among patients taking direct oral anticoagulants (DOACs) have been associated with low...
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Psychiatric implications of anti-seizure medications in epileptic population
Background and objectiveEpilepsy is a prevalent neurological disorder that affects a significant number of individuals globally. This condition is...
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Levetiracetam versus Phenobarbitone for Management of Neonatal Seizures: A Systematic Review and Meta-analysis
ObjectivesTo review whether levetiracetam is non-inferior to phenobarbitone as the first-choice antiseizure medication (ASM).
MethodsThe authors...
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When Drugs Do Not Work: Alternatives to Antiseizure Medications
Purpose of ReviewDespite the increase in the number of novel antiseizure medications over the past 20 years, approximately one-third of patients will...
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Ketamine reduces seizure and interictal continuum activity in refractory status epilepticus: a multicenter in-person and teleneurocritical care study
BackgroundThere is not a preferred medication for treating refractory status epilepticus (RSE) and intravenous ketamine is increasingly used....
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Assessment of serum complement level in a sample of patients of idiopathic childhood epilepsy
BackgroundThe etiology of epilepsy is still unknown in over a third of cases and a third of patients have seizures resistant to current antiseizure...
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The impact of parent treatment preference and other factors on recruitment: lessons learned from a paediatric epilepsy randomised controlled trial
BackgroundIn paediatric epilepsy, the evidence of effectiveness of antiseizure treatment is inconclusive for some types of epilepsy. As with other...
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An Update on Stiripentol Mechanisms of Action: A Narrative Review
Stiripentol (Diacomit ® ) (STP) is an orally active antiseizure medication (ASM) indicated as adjunctive therapy, for the treatment of seizures...
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New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: I. Role of GABA as a Modulator of Seizure Activity and Recently Approved Medications Acting on the GABA System
γ-Aminobutyric acid (GABA) is the most prevalent inhibitory neurotransmitter in the mammalian brain and has been found to play an important role in...
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COVID-19 vaccination uptake in children with epilepsy and vaccine hesitancy among their parents: a survey
This study explored the coronavirus disease 2019 (COVID-19) vaccination coverage among children with epilepsy (CwE), factors affecting vaccination...
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Association between anti-seizure medication and outcomes in infants
ObjectiveTo compare treatment failure between: (1) infants treated with phenobarbital versus levetiracetam for first-line treatment and (2) infants...
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Effect of Cenobamate on Cognition in Patients with Drug-Resistant Epilepsy with Focal Onset Seizures: An Exploratory Study
Background and ObjectiveMost second and third generation antiseizure medications (ASMs) are associated with cognitive adverse events, which are a...
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Seizures and epilepsy in patients with ischaemic stroke
BackgroundWith the increased efficacy of stroke treatments, diagnosis and specific treatment needs of patients with post-stroke seizures (PSS) and...
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Driving eligibility following acute symptomatic seizure with structural brain lesion – English Version
Acute symptomatic seizures are often caused by acute structural brain lesions. However, German guidelines for driving eligibility do not cover this...
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Pediatric Status Epilepticus: Treat Early and Avoid Delays
Pediatric convulsive status epilepticus (cSE) is a neurologic emergency with potential for morbidity and mortality. Rapid treatment and escalation of...
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Care of Children with Infantile Epileptic Spasms Syndrome and Applicability of Telemedicine Amidst the COVID-19 Pandemic
This ambispective, observational study evaluated the impact of the COVID-19 pandemic on managing children with Infantile epileptic spasms syndrome...
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Proposed Recommendations for the Management of Depression in Adults with Epilepsy: An Expert Consensus
IntroductionExperts agree that there is a need for protocols to guide health professionals on how to best manage psychiatric comorbidities in...
