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Thrombotic microangiopathy with transiently positive direct Coombs test in an adult with poststreptococcal acute glomerulonephritis: a case report
BackgroundTo date, a few case reports have described the association between poststreptococcal acute glomerulonephritis (PSAGN) and hemolytic...
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Corpus luteum presence in the bovine ovary increase intrafollicular progesterone concentration: consequences in follicular cells gene expression and follicular fluid small extracellular vesicles miRNA contents
BackgroundIt is well described that circulating progesterone (P4) plays a key role in several reproductive events such as oocyte maturation. However,...
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Cordycepin alleviates osteoarthritis by inhibiting chondrocyte ferroptosis via Keap1/Nrf2 axis
BackgroundIntervertebral disc degeneration (IVDD) is a prevalent condition known to contribute to lower back pain and various spinal disorders. The...
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Efficacy of knee-balancing manipulation plus heat-sensitive moxibustion for knee osteoarthritis and its influence on CTX- I, TRACP-5b, ADAMTS-4, and MMP-3
ObjectiveTo observe the efficacy of knee-balancing manipulation plus heat-sensitive moxibustion in treating knee osteoarthritis (KOA) and its impact...
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Evaluation of a rapid turn-over, fully-automated ADAMTS13 activity assay: a method comparison study
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy caused by severely reduced activity of the von-Willebrand...
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Thrombotic thrombocytopenic purpura in a patient on long-term alpha-interferon therapy for essential thrombocythemia: a case report
BackgroundThrombotic thrombocytopenic purpura (TTP) is rare and severe thrombotic microangiopathy characterized by thrombocytopenia, hemolytic...
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The role of serum ADAMTS-1 levels in Hyperemesis Gravidarum
BackgroundWe aimed to investigate the levels of ADAMTS-1, which is secreted from the extracellular matrix during trophoblastic invasion in...
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Ginsenoside Rg1 inhibits nucleus pulposus cell apoptosis, inflammation and extracellular matrix degradation via the YAP1/TAZ pathway in rats with intervertebral disc degeneration
PurposeIntervertebral disc degeneration (IDD) is one of the main causes of low back pain, which not only affects patients’ life quality, but also...
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Pure platelet-rich plasma promotes semaphorin-3A expression: a novel insight to ameliorate intervertebral disk degeneration in vitro
IntroductionIntervertebral disk degeneration (IVDD) can be effectively treated using platelet-rich plasma (PRP). While the exact process is fully...
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Extracellular vesicles, hyperadhesive von willebrand factor, and outcomes of gastric cancer: a clinical observational study
Von Willebrand factor (VWF) is an adhesive ligand critical for maintaining hemostasis. However, it has also been increasingly recognized for its role...
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Unravelling morphoea aetiopathogenesis by next-generation sequencing of paired skin biopsies
BackgroundMorphoea can have a significant disease burden. Aetiopathogenesis remains poorly understood, with very limited existing genetic studies....
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Reversible skin microvascular hyporeactivity in patients with immune-mediated thrombocytopenic thrombotic purpura
BackgroundImmune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare disease characterized by arteriolar and capillary microthrombosis...
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Inhibition of miR-96-5p alleviates intervertebral disc degeneration by regulating the peroxisome proliferator-activated receptor γ/nuclear factor-kappaB pathway
BackgroundIntervertebral disc degeneration (IDD) is the main pathogenesis of low back pain. MicroRNAs (miRNAs) have been found to exert regulatory...
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Induction of cervical disc degeneration and discogenic pain by low concentration Propionibacterium acnes infection: an in vivo animal study
BackgroundAlthough cervical intervertebral disc (IVD) degeneration is closely associated with neck pain, its cause remains unclear. In this study, an...
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Astragaloside IV attenuates IL-1β-induced intervertebral disc degeneration through inhibition of the NF-κB pathway
BackgroundIntervertebral disc degeneration (IDD) is the main cause of low back pain. Patients with low back pain may experience significant...
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Sema4D as a biomarker for Predicting rheumatoid arthritis disease activity
ObjectiveThe semaphorins are membrane or secreted proteins first identified in neural development. Semaphorin 4D (Sema4D) is the first family member...
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Small molecules of herbal origin for osteoarthritis treatment: in vitro and in vivo evidence
Osteoarthritis (OA) is one of the most common musculoskeletal degenerative diseases and contributes to heavy socioeconomic burden. Current...
