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Tc-HDP quantitative SPECT/CT in transthyretin cardiac amyloid and the development of a reference interval for myocardial uptake in the non-affected population
Background99mTechnetium-HDP (HDP) bone scans differentiate transthyretin (ATTR) cardiac amyloid from other infiltrative myocardial diseases. These...
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Application of a machine learning approach to characterization of liver function using 99mTc-GSA SPECT/CT
PurposeTo assess the utility of a machine-learning approach for predicting liver function based on technetium-99 m-galactosyl serum albumin ( 99m Tc-GS...
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Test–retest repeatability of quantitative bone SPECT/CT
ObjectiveTechnological innovations in single-photon emission computed tomography (SPECT) have enabled a more accurate quantitative evaluation of the...
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Performance assessment of the ALBIRA II pre-clinical SPECT S102 system for 99mTc imaging
ObjectiveThe performance characteristics of the SPECT sub-system S102 of the ALBIRA II PET/SPECT/CT are analyzed for the 80 mm field of view (FOV) to...
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A new SPECT/CT reconstruction algorithm: reliability and accuracy in clinical routine for non-oncologic bone diseases
BackgroundxSPECT Bone® (xB) is a new reconstruction algorithm developed by Siemens® in bone hybrid imaging (SPECT/CT). A CT-based tissue segmentation...
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Theranostic SPECT reconstruction for improved resolution: application to radionuclide therapy dosimetry
BackgroundSPECT-derived dose estimates in tissues of diameter less than 3× system resolution are subject to significant losses due to the limited...
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Establishment of a clinical SPECT/CT protocol for imaging of 161Tb
BackgroundIt has been proposed, and preclinically demonstrated, that 161 Tb is a better alternative to 177 Lu for the treatment of small prostate...
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First experience of durable cytoreduction in chronic lymphoid leukemia with 177Lu-DOTATATE
This is the first described case of effective and durable cytoreduction after PRRT with 177 Lu-DOTATATE in a 75-year-old female, with B cell chronic...
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Does quantification have a role to play in the future of bone SPECT?
Routinely, there is a visual basis to nuclear medicine reporting: a reporter subjectively places a patient’s condition into one of multiple discrete...
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The effect of calibration factors and recovery coefficients on 177Lu SPECT activity quantification accuracy: a Monte Carlo study
BackgroundDifferent gamma camera calibration factor (CF) geometries have been proposed to convert SPECT data into units of activity concentration....
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Quantification of osteoblastic activity in epiphyseal growth plates by quantitative bone SPECT/CT
ObjectiveQuantifying the function of the epiphyseal plate is worthwhile for the management of children with growth disorders. The aim of this...
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Evaluation of bone metastatic burden by bone SPECT/CT in metastatic prostate cancer patients: defining threshold value for total bone uptake and assessment in radium-223 treated patients
ObjectivesTo establish a new three-dimensional quantitative evaluation method for bone metastasis, we applied bone single photon emission tomography...
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Automated segmentation and detection of increased uptake regions in bone scintigraphy using SPECT/CT images
PurposeTo develop a method for automated detection of highly integrated sites in SPECT images using bone information obtained from CT images in bone...
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Skeletal standardized uptake values obtained by quantitative SPECT/CT as an osteoblastic biomarker for the discrimination of active bone metastasis in prostate cancer
PurposeTo investigate the improvement of prognostication of active bone metastatic burden by discriminating bone metastases from degenerative changes...