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The value of time-dependent risk predictions in a screening context - a comprehensive simulation analysis validated on German cancer registry data
BackgroundRisk-prediction tools allow classifying individuals into risk groups based on risk thresholds. Such risk categorization is often used to...
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Integrating Functional Imaging and Molecular Profiling for Optimal Treatment Selection in Neuroendocrine Neoplasms (NEN)
Purpose of ReviewGastroenteropancreatic NEN (GEP-NEN) are group of malignancies with significant clinical, anatomical and molecular heterogeneity....
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A roadmap for sex- and gender-disaggregated health research
Sex and gender are fundamental aspects of health and wellbeing. Yet many research studies fail to consider sex or gender differences, and even when...
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Sex and Gender-related Disparities in Clinical Characteristics and Outcomes in Heart Transplantation
Abstract Purpose of ReviewLimited research has been conducted on sex disparities in heart transplant (HT). The aim of this review is to analyse the...
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Decision support system to evaluate ventilation in the acute respiratory distress syndrome (DeVENT study)—trial protocol
BackgroundThe acute respiratory distress syndrome (ARDS) occurs in response to a variety of insults, and mechanical ventilation is life-saving in...
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Towards a New Classification of Cardiomyopathies
Purpose of ReviewThe aim of this paper is to briefly summarise the clinical approach to disease notation for cardiomyopathies and to highlight its...
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Psychotherapy or medication for depression? Using individual symptom meta-analyses to derive a Symptom-Oriented Therapy (SOrT) metric for a personalised psychiatry
BackgroundAntidepressant medication (ADM) and psychotherapy are effective treatments for major depressive disorder (MDD). It is unclear, however, if...
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Barriers and facilitators for recruiting and retaining male participants into longitudinal health research: a systematic review
BackgroundSuccessfully recruiting male participants to complete a healthcare related study is important for healthcare study completion and to...
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Prognostic models predicting transition to psychotic disorder using blood-based biomarkers: a systematic review and critical appraisal
Accumulating evidence suggests individuals with psychotic disorder show abnormalities in metabolic and inflammatory processes. Recently, several...
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Development and validation of a screening questionnaire for early identification of pregnant women at risk for excessive gestational weight gain
BackgroundExcessive weight gain during pregnancy is associated with adverse health outcomes for mother and child. Intervention strategies to prevent...
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Develo** a clinical decision support system software prototype that assists in the management of patients with self-harm in the emergency department: protocol of the PERMANENS project
BackgroundSelf-harm presents a significant public health challenge. Emergency departments (EDs) are crucial healthcare settings in managing...
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A Multimodal Omics Framework to Empower Target Discovery for Cardiovascular Regeneration
Ischaemic heart disease is a global healthcare challenge with high morbidity and mortality. Early revascularisation in acute myocardial infarction...
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Precision nutrition for targeting pathophysiology of cardiometabolic phenotypes
Obesity is a heterogenous disease accompanied by a broad spectrum of cardiometabolic risk profiles. Traditional paradigms for dietary weight...
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Impact of the 12-gene recurrence score in influencing adjuvant chemotherapy prescription in mismatch repair proficient stage II/III colonic carcinoma—a systematic review and meta-analysis
IntroductionThe 12-gene recurrence score (RS) is a clinically validated assay which predicts recurrence risk in patients with stage II/III colon...
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A randomised controlled unblinded multicentre non-inferiority trial with activated vitamin D and prednisolone treatment in patients with minimal change nephropathy (ADAPTinMCN)
BackgroundMinimal change nephropathy (MCN) is a common cause of nephrotic syndrome in both adults and children. International guidelines recommend...
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Accounting for Capacity Constraints in Economic Evaluations of Precision Medicine: A Systematic Review
Background and ObjectivePrecision (stratified or personalised) medicine is underpinned by the premise that it is feasible to identify known...
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Monogenic and polygenic concepts in chronic kidney disease (CKD)
Kidney function is strongly influenced by genetic factors with both monogenic and polygenic factors contributing to kidney function. Monogenic...
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Study protocol for a pragmatic cluster RCT on the effect and cost-effectiveness of Everyday Life Rehabilitation versus treatment as usual for persons with severe psychiatric disability living in sheltered or supported housing facilities
BackgroundPeople with severe psychiatric disabilities and impaired autonomy, living in sheltered or supported housing facilities, often lead...
