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Single cell transcriptomics reveal the heterogeneities of TCR Vα7.2+CD161+ and TCR Vα7.2+CD161− T cells in human peripheral blood
PurposeT cell receptor (TCR) usually determines the specificity and unique function of T cells. Recently, the unconventional T cells with a unique...
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Disease- and headache-specific microRNA signatures and their predicted mRNA targets in peripheral blood mononuclear cells in migraineurs: role of inflammatory signalling and oxidative stress
BackgroundMigraine is a primary headache with genetic susceptibility, but the pathophysiological mechanisms are poorly understood, and it remains an...
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DNA damage and repair in peripheral blood mononuclear cells after internal ex vivo irradiation of patient blood with 131I
AimThe aim of this study was to provide a systematic approach to characterize DNA damage induction and repair in isolated peripheral blood...
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Deep immunophenoty** reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood
BackgroundEndometriosis is a chronic, estrogen-dependent disorder where inflammation contributes to disease-associated symptoms of pelvic pain and...
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Results of a prospective observational study of autologous peripheral blood mononuclear cell therapy for no-option critical limb-threatening ischemia and severe diabetic foot ulcers
BackgroundCell therapy with autologous peripheral blood mononuclear cells (PB-MNCs) may help restore limb perfusion in patients with diabetes...
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Effectiveness of single-dose 6 mg pegfilgrastim in mobilizing peripheral blood stem cells in allogeneic hematopoietic cell transplantation donors
A single injection of 12 mg pegfilgrastim was used to mobilize peripheral blood progenitor cells (PBPCs) from healthy donors in some studies. The...
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Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage
Aims/hypothesisEnteroviral infection has been implicated consistently as a key environmental factor correlating with the appearance of autoimmunity...
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Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus
PurposeObstructive sleep apnea (OSA) is characterised by increased systemic inflammation, and is often accompanied with type 2 diabetes mellitus...
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Identification of circular RNAs hsa_circ_0140271 in peripheral blood mononuclear cells as a novel diagnostic biomarker for female rheumatoid arthritis
BackgroundRheumatoid arthritis (RA) is a chronic autoimmune disease, which commonly affects women. Accumulating evidence shows that differentially...
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Resistin, TNF-α, and microRNA 124-3p expressions in peripheral blood mononuclear cells are associated with diabetic nephropathy
IntroductionDiabetic nephropathy causes chronic kidney disease and renal failure globally. We investigated the mRNA expression of resistin, TNF-α,...
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Long-term changes of Th17 and regulatory T cells in peripheral blood of dogs with spinal cord injury after intervertebral disc herniation
BackgroundIntervertebral disc herniation (IVDH) is one of the most common causes of spinal cord injury (SCI) in dogs. As a result of acute SCI, a...
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Expression of TRAF6 in peripheral blood B cells of patients with myasthenia gravis
BackgroundTumor necrosis factor receptor-associated factor 6 (TRAF6) can regulate the activation of inflammatory signaling pathways by acting as an...
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Reduced Th1 response is associated with lower glycolytic activity in activated peripheral blood mononuclear cells after metabolic and bariatric surgery
BackgroundObesity promotes cellular immunometabolism changes that trigger the activation of macrophages and lymphocytes, leading to systemic...
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HLA class II antibody activation of endothelial cells induces M2 macrophage differentiation in peripheral blood
BackgroundDonor-specific human leukocyte antigen (HLA) class II antibodies (HLA-II Abs) combined with allogeneic endothelial cells (ECs) mediate...
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Diagnostic significance of peripheral blood indices for eosinophilic chronic rhinosinusitis in Chinese adults
ObjectiveEosinophilic chronic rhinosinusitis (eCRS) is a refractory subtype of CRS. This study aimed to compare the differences in clinical features...
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Lymphocyte profile in peripheral blood of patients with multiple myeloma
Multiple myeloma (MM) is a disease which remains incurable. One of the main reasons is a weakened immune system that allows MM cells to survive....
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The tissue-resident marker CD103 on peripheral blood T cells predicts responses to anti-PD-1 therapy in gastric cancer
BackgroundImmune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. Since clinical benefits are limited to a subset of patients, we...
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Single-cell characterization of a model of poly I:C-stimulated peripheral blood mononuclear cells in severe asthma
BackgroundAsthma has been associated with impaired interferon response. Multiple cell types have been implicated in such response impairment and may...
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Generation of Autologous Vascular Endothelial Cells for Patients with Peripheral Artery Disease
AbstractPeripheral artery disease (PAD) is a prevalent cardiovascular disease with risks of limb loss. Our objective is to establish an autologous...
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Peripheral neuropathy associated with chronic lymphoproliferative disorders of natural killer cells (CLPD-NK): a case report and literature review
BackgroundChronic lymphoproliferative disorders of natural killer cells (CLPD-NK) is a rare lymphoproliferative disease. Peripheral neuropathy is an...
