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Disease Progression and Longitudinal Clinical Outcomes of Lewy Body Dementia in the NACC Database
IntroductionAs the identification of Lewy body dementia (LBD) is often confirmed postmortem, there is a paucity of evidence on the progression of...
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Mortality in nursing home residents stratified according to subtype of dementia: a longitudinal study over three years
BackgroundThere are several subtypes of dementia caused by different pathophysiology and with different clinical characteristics. Irrespective...
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Diagnostic and therapeutic agents that target alpha-synuclein in Parkinson’s disease
The development of disease-modifying drugs and differential diagnostic agents is an urgent medical need in Parkinson’s disease. Despite the complex...
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The brain-first vs. body-first model of Parkinson’s disease with comparison to alternative models
The ultimate origin of Lewy body disorders, including Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB), is still incompletely understood....
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Diagnostic value of plasma SIRT1 levels and whole-brain gray matter volume in Parkinson’s disease patients with cognitive impairment
ObjectiveThis study was designed to investigate the diagnostic value of plasma SIRT1 levels and whole-brain gray matter (GM) volume in Parkinson’s...
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Polysomnographic Predictors of Sleep, Motor, and Cognitive Dysfunction Progression in Parkinson’s Disease
Purpose of ReviewSleep disturbances are an important nonmotor feature of Parkinson’s disease (PD) that can cause polysomnographic (PSG) alterations....
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Genetic analysis of the LRP10 gene in Chinese patients with Parkinson’s disease
BackgroundParkinson’s disease (PD) is a neurodegenerative disorder characterized by resting tremor, bradykinesia, muscle rigidity, and abnormal gait....
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Multimodal visual system analysis as a biomarker of visual hallucinations in Parkinson’s disease
Visual hallucinations (VH) are present in up to 75% of Parkinson’s disease (PD) patients. However, their neural bases and participation of the visual...
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The role of immune and inflammatory-related indicators in cognitive dysfunction and disease severity in patients with parkinson’s disease
We aimed to explore the role of immune and inflammatory indicators in cognitive dysfunction and disease severity in patients with Parkinson's...
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The ‘α-synucleinopathy syndicate’: multiple system atrophy and Parkinson’s disease
Multiple System Atrophy (MSA) and Parkinson’s diseases (PD) are elite members of the α-synucleinopathy organization. Aberrant accumulations of the...
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Effect of cognitive reserve on cognitive function in Parkinson’s disease
BackgroundPrevious studies showed inconsistent results for the correlation between cognitive reserve (CR) and cognitive function in Parkinson’s...
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Loss of the “swallow tail sign” on susceptibility-weighted imaging in the diagnosis of dementia with Lewy bodies: a systematic review and meta-analysis
IntroductionLoss of dorsolateral nigral hyperintensity (DNH) on iron-sensitive brain MRI is useful for Parkinson’s disease detection. DNH loss could...
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Screening for non-motor symptoms in Egyptian patients with Parkinson’s disease
BackgroundMost of the patients with Parkinson’s disease (PD) suffer from non-motor symptoms (NMS). Despite their marked effect on patients’ quality...
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Analysis of the LRP10 gene in patients with Parkinson’s disease and dementia with Lewy bodies from Southern Italy
Recently, the LRP10 gene has been associated with Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), and dementia with Lewy bodies...
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The role of 123-I-MIBG cardiac scintigraphy in the differential diagnosis between dementia with Lewy bodies and Alzheimer’s disease
Although detailed diagnostic guidelines are available, differentiating dementia with Lewy bodies from Alzheimer’s disease is often difficult....
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Toxic interactions between dopamine, α-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson’s disease
Parkinson’s disease is characterized by its distinct pathological features; loss of dopamine neurons in the substantia nigra pars compacta and...
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Mid- and late-life lifestyle activities as main drivers of general and domain-specific cognitive reserve in individuals with Parkinson’s disease: cross-sectional and longitudinal evidence from the LANDSCAPE study
BackgroundCognitive reserve (CR) is considered a protective factor for cognitive function and may explain interindividual differences of cognitive...
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Plasma arylsulfatase A levels are associated with cognitive function in Parkinson’s disease
BackgroundArylsulfatase A (ARSA), a lysosomal enzyme, has been shown to inhibit the aggregation and propagation of α-synuclein (α-syn) through its...
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Peripheral immune profile in drug-naïve dementia with Lewy bodies
BackgroundAccumulating evidence suggests that peripheral inflammation is associated with the pathogenesis of Parkinson’s disease (PD). We examined...
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Gray matter loss relates to dual task gait in Lewy body disorders and aging
BackgroundWithin the spectrum of Lewy body disorders (LBD), both Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are characterized by...
