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Quantitative Analysis of [18F]FMISO PET for Tumor Hypoxia: Correlation of Modeling Results with Immunohistochemistry
PurposeQuantitative evaluation of tumor hypoxia based on H -1-(3-[ 18 F]fluoro-2-hydroxypropyl)-2-nitroimidazole ([ 18 F]FMISO) positron emission...
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Hypoxia in Melanoma: Using Optical Spectroscopy and EF5 to Assess Tumor Oxygenation Before and During Regional Chemotherapy for Melanoma
BackgroundThere is increasing evidence that tumor hypoxia plays a significant role in the chemoresistance of melanoma, but to our knowledge,...
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Quantitative and qualitative analysis of [18F]FDG and [18F]FAZA positron emission tomography of head and neck cancers and associations with HPV status and treatment outcome
PurposeWhile methods for imaging tumor hypoxia with positron emission tomography (PET) have been developed, optimal methods for interpreting and...
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Molecular imaging of hypoxia in non-small-cell lung cancer
Non-small-cell lung cancer (NSCLC) is the commonest cancer worldwide but survival remains poor with a high risk of relapse, particularly after...
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Evaluation of CAIX and CAXII Expression in Breast Cancer at Varied O2 Levels: CAIX is the Superior Surrogate Imaging Biomarker of Tumor Hypoxia
PurposeHypoxia is commonly observed in regions of primary tumors and metastases, and is associated with resistance to treatment, more aggressive...
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Reactive oxygen species production has a critical role in hypoxia-induced Stat3 activation and angiogenesis in human glioblastoma
Glioblastoma is the most aggressive primary brain tumor with hypoxia-associated morphologic features including pseudopalisading necrosis and...
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The role of PET/CT in the management of patients affected by head and neck tumors: a review of the literature
The management of head and neck tumor (HNSCC) has been changing over the years, especially due to the aid of imaging techniques that help physicians...
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Potential Contributions of Intimal and Plaque Hypoxia to Atherosclerosis
Injury of arterial endothelium by abnormal shear stress and other insults induces migration and proliferation of vascular smooth muscle cells...
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PET imaging biomarkers in head and neck cancer
In locally advanced head and neck squamous cell carcinoma (HNSCC), the role of imaging becomes more and more critical in the management process. In...
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Synergistic action of image-guided radiotherapy and androgen deprivation therapy
The combined use of androgen deprivation therapy (ADT) and image-guided radiotherapy (IGRT) can improve overall survival in aggressive, localized...
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Detecting functional changes with [18F]FAZA in a renal cell carcinoma mouse model following sunitinib therapy
BackgroundThe multitargeting tyrosine kinase inhibitor (TKI) sunitinib is currently the first-line drug therapy for metastasizing renal cell...
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A prospective clinical study of 18 F-FAZA PET-CT hypoxia imaging in head and neck squamous cell carcinoma before and during radiation therapy
PurposeHypoxia in head and neck squamous cell carcinoma (HNSCC) is associated with poor prognosis and outcome. 18 F-Fluoroazomycin arabinoside...
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Using google street view for systematic observation of the built environment: analysis of spatio-temporal instability of imagery dates
BackgroundRecently, Google Street View (GSV) has been examined as a tool for remotely conducting systematic observation of the built environment....
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Scheduling of paclitaxel and gefitinib to inhibit repopulation for optimal treatment of human cancer cells and xenografts that overexpress the epidermal growth factor receptor
PurposeIn clinical studies, evaluating the combination of chemotherapy and the epidermal growth factor receptor (EGFR) inhibitor gefitinib,...
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Electrophilic Addition of Chlorine Monofluoride for PET tracers
PurposeWe have studied the utility of [ 18 F]ClF electrophilic addition to the carbon–carbon double bond of analogues of a model positron emission...
