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Refractory ventricular tachycardia and heart failure due to anti-mitochondrial antibody-positive inflammatory myopathy
BackgroundAnti-mitochondrial antibody (AMA)-positive inflammatory myopathy, a rare type of idiopathic inflammatory myopathy which was frequently...
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What is the actual relationship between neutrophil extracellular traps and COVID-19 severity? A longitudinal study
BackgroundNeutrophil extracellular traps (NETs) have repeatedly been related to COVID-19 severity and mortality. However, there is no consensus on...
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Retinal thickness as a biomarker of cognitive impairment in manifest Huntington’s disease
BackgroundCognitive decline has been reported in premanifest and manifest Huntington’s disease but reliable biomarkers are lacking. Inner retinal...
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Plasma Metabonomics of Human Adenovirus-infected Patients with Pneumonia and Upper Respiratory Tract Infection
ObjectiveHuman adenovirus (HAdV) infection is common and can develop to serious conditions with high mortality, yet the mechanism of HAdV infection...
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Metabolic syndrome and thyroid Cancer: risk, prognosis, and mechanism
The increasing incidence of thyroid cancer (TC) cannot be fully explained by overdiagnosis. Metabolic syndrome (Met S) is highly prevalent due to the...
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Structural alterations of spinocerebellar ataxias type 3: from pre-symptomatic to symptomatic stage
ObjectivesTo investigate and characterize the structural alterations of the brain in SCA3, and their correlations with the scale for the assessment...
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Does Regular Physical Activity Mitigate the Age-Associated Decline in Pulmonary Function?
Whereas the negative effects of aging and smoking on pulmonary function are undisputed, the potential favorable effects of physical activity on the...
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Safety, Tolerability and Pharmacokinetics of Single-Dose Oral SYHA1402 in Healthy Chinese Subjects
IntroductionTo assess the safety, tolerability and pharmacokinetics of a single dose of SYHA1402 in healthy Chinese subjects.
Methods ...
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Sirtfood intake in relation to the 10-year risk of major adverse cardiovascular events: a population-based cohort study
BackgroundSirtuins have an important role in the regulation of metabolic and biological processess. Thus, we hypothesized that foods that could...
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Polymorphism rs5780218, rs12998 and rs10158616 in KISS1 gene among the Hubei province Chinese girls with the central precocious puberty
PurposeCentral precocious puberty (CPP) results from early activation of the hypothalamic-pituitary-gonadal (HPG) axis. To elucidate the molecular...
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Dietary Inflammatory Index and diabetic retinopathy risk in US adults: findings from NHANES (2005–2008)
BackgroundInflammation is associated with the pathophysiology of diabetic retinopathy (DR). Within the framework of complete dietary patterns, the...
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The m6A demethylase FTO targets POLQ to promote ccRCC cell proliferation and genome stability maintenance
Background and aimAs the first identified m 6 A demethylase, FTO has been implicated in the progression of various cancers. However, the specific...
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Lactate dehydrogenase as promising marker for prognosis of brain metastasis
BackgroundLactate dehydrogenase (LDH) is a biomarker for cancer. However, the relationship between serum LDH levels and the survival of patients with...
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Metabolite changes in the posterior cingulate cortex could be a signature for early detection of Alzheimer’s disease: a systematic review and meta-analysis study based on 1H-NMR
BackgroundPosterior cingulate cortex (PCC) is a paralimbic cortical structure with a fundamental role in integrative functions of the default mode...
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A review on epilepsy, current treatments, and potential of medicinal plants as an alternative treatment
Epilepsy is considered common neurological diseases that threaten the lives of millions of people all around the world. Since ancient times,...
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Genetic markers of cardiac autonomic neuropathy in the Kazakh population
BackgroundCardiac autonomic neuropathy (CAN) is a complication of diabetes mellitus (DM) that increases the risk of morbidity and mortality by...
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Treatment of Ovarian Cancer Beyond PARP Inhibition: Current and Future Options
Ovarian cancer is the leading cause of gynecological cancer death. Improved understanding of the biologic pathways and introduction of poly...
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Use of homeopathy in feeding piglets as an alternative to reduce fighting behavior in the nursery phase: effects on production and hematological, metabolic, and oxidative variables
This study aimed to determine whether using a homeopathic agent would improve the behavior, growth performance, redox status, and neuroimmune...
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Endothelin A receptor blocker and calcimimetic in the adenine rat model of chronic renal insufficiency
BackgroundWe studied whether endothelin receptor antagonist and calcimimetic treatments influence renal damage and kidney renin-angiotensin (RA)...
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Ameliorative influence of Garcinia kola seed extracts against multiple organ toxicity in monosodium glutamate-administered Wistar rats
Monosodium glutamate (MSG) is a food additive that can be toxic to multiple organs of the body. It has been demonstrated that Garcinia kola seed has...
