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Drugs in Development to Treat IgA Nephropathy
IgA nephropathy is a common glomerulonephritis consequent to the autoimmune response to aberrant glycosylated immunoglobulin (Ig) A antibodies....
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The SCRIPT trial: study protocol for a randomised controlled trial of a polygenic risk score to tailor colorectal cancer screening in primary care
BackgroundPolygenic risk scores (PRSs) can predict the risk of colorectal cancer (CRC) and target screening more precisely than current guidelines...
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Extended-release pharmacotherapy for opioid use disorder (EXPO): protocol for an open-label randomised controlled trial of the effectiveness and cost-effectiveness of injectable buprenorphine versus sublingual tablet buprenorphine and oral liquid methadone
BackgroundSublingual tablet buprenorphine (BUP-SL) and oral liquid methadone (MET) are the daily, standard-of-care (SOC) opioid agonist treatment...
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Understanding the Clinical Implications of Individual Patient Characteristics and Treatment Choice on the Risk of Exacerbation in Asthma Patients with Moderate–Severe Symptoms
IntroductionThe assessment of future risk has become an important feature in the management of patients with asthma. However, the contribution of...
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The Genetic Factors Influencing Cardiomyopathies and Heart Failure across the Allele Frequency Spectrum
Heart failure (HF) remains a major cause of mortality and morbidity worldwide. Understanding the genetic basis of HF allows for the development of...
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HealthyRHearts - reducing cholesterol in rural adults via telehealth-based medical nutrition therapy: protocol for a cluster randomised controlled trial
BackgroundFew randomised controlled trials specifically focus on prevention in rural populations. Cardiovascular disease (CVD) contributes to...
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Gross tumour volume radiomics for prognostication of recurrence & death following radical radiotherapy for NSCLC
Recurrence occurs in up to 36% of patients treated with curative-intent radiotherapy for NSCLC. Identifying patients at higher risk of recurrence for...
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Status and Quality of Guidelines for Therapeutic Drug Monitoring Based on AGREE II Instrument
BackgroundWith the progress of therapeutic drug monitoring (TDM) technology and the development of evidence-based medicine, many guidelines were...
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Supporting patients to get the best from their osteoporosis treatment: a rapid realist review of what works, for whom, and in what circumstance
SummarySystematic reviews that examine effectiveness of interventions to improve medicines optimisation do not explain how or why they work. This...
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Trajectories of chronic multimorbidity patterns in older patients: MTOP study
BackgroundMultimorbidity is associated with negative results and poses difficulties in clinical management. New methodological approaches are...
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Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
The convergence of advances in medical science, human biology, data science and technology has enabled the generation of new insights into the...
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Effectiveness of cannabis use and cannabis use disorder interventions: a European and international data synthesis
This data synthesis examined the effectiveness of behavioural and pharmacological approaches for cannabis treatment. We integrated findings from high...
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A Multidisciplinary Approach Is Beneficial in Atopic Dermatitis
Atopic dermatitis (AD) is a highly heterogeneous chronic inflammatory skin disorder that is frequently associated with a plethora of comorbidities....
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Effectiveness of a telehealth-delivered clinician-supported exercise and weight loss program for hip osteoarthritis – protocol for the Better Hip randomised controlled trial
BackgroundHip osteoarthritis (OA) is a leading cause of chronic pain and disability worldwide. Self-management is vital with education, exercise and...
