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suPAR cut-offs for stratification of low, medium, and high-risk acute medical patients in the emergency department
BackgroundSoluble urokinase plasminogen activator receptor (suPAR) levels have previously been associated with readmission and mortality in acute...
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Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer
The urokinase plasminogen activator receptor (uPAR) plays a multifaceted role in almost any process where migration of cells and tissue-remodeling is...
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Pre-hospital suPAR, lactate and CRP measurements for decision-making: a prospective, observational study of patients presenting non-specific complaints
BackgroundIn the pre-hospital setting, non-urgent patients with non-specific chief complaints pose assessment challenges for the emergency medical...
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The diagnostic value of soluble urokinase-type plasminogen activator receptor (suPAR) for the discrimination of vertebral osteomyelitis and degenerative diseases of the spine
BackgroundThere is still a challenge in discriminating between vertebral osteomyelitis and degenerative diseases of the spine. To this end, we...
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Association between variables measured in the ambulance and in-hospital mortality among adult patients with and without infection: a prospective cohort study
BackgroundPatients presenting with infection to the ambulance are common, but risk factors for poor outcome are not known. The primary aim of the...
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What is circulating factor disease and how is it currently explained?
Nephrotic syndrome (NS) consists of the clinical triad of hypoalbuminaemia, high levels of proteinuria and oedema, and describes a heterogeneous...
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Prognostic value of suPAR and hsCRP on acute kidney injury after cardiac surgery
BackgroundAcute kidney injury (AKI) represents a serious complication following cardiac surgery. Adverse outcome after cardiac surgery has been...
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Soluble urokinase-type plasminogen activator receptor represents exercise tolerance and predicts adverse cardiac events in patients with heart failure
Soluble urokinase-type plasminogen activator receptor (suPAR) is a membrane-binding protein that is released into the blood stream by immune...
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Transitions of blood immune endotypes and improved outcome by anakinra in COVID-19 pneumonia: an analysis of the SAVE-MORE randomized controlled trial
BackgroundEndotype classification may guide immunomodulatory management of patients with bacterial and viral sepsis. We aimed to identify immune...
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Rationale and design of the Japanese Biomarkers in Nephrotic Syndrome (J-MARINE) study
IntroductionDisease subty** and monitoring are essential for the management of nephrotic syndrome (NS). Although various biomarkers for NS have...
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Inflammatory burden of adolescents with childhood maltreatment: results from baseline data of a school cohort
Increasing studies have investigated inflammatory burden of adults with childhood adversity, but less is known about how childhood maltreatment...
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Anakinra for the treatment of COVID-19 patients: a systematic review and meta-analysis
BackgroundAt the end of 2021, the European Medicines Agency (EMA) expanded its approval for the recombinant human interleukin-1 (IL-1) receptor...
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Soluble Urokinase-Type Plasminogen Activator Receptor and Arterial Stiffness in Patients with COPD
IntroductionSoluble urokinase-type plasminogen activator receptor (suPAR) is upregulated by inflammation and plays a role in the pathogenesis of...
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Predictive value of soluble urokinase-type plasminogen activator receptor for mortality in patients with suspected myocardial infarction
BackgroundEarly risk stratification of patients with suspected acute myocardial infarction (AMI) constitutes an unmet need in current daily clinical...
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Increased soluble urokinase plasminogen activator receptor (suPAR) levels in neovascular age-related macular degeneration: a role for inflammation in the pathogenesis of the disease?
PurposeTo evaluate the plasma concentration of the soluble form of the urokinase-type plasminogen activator receptor ((s)uPAR), an established...
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Soluble Urokinase Plasminogen Activator Receptor (suPAR) as an Added Predictor to Existing Preoperative Risk Assessments
BackgroundRisk assessment strategies, such as using the American Society of Anesthesiologists (ASA) physical status classification, attempt to...
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Concentration of soluble urokinase plasminogen activator receptor (suPAR) in the pre-ovulatory follicular fluid is associated with development of ovarian hyperstimulation syndrome during ovarian stimulation
PurposeInvestigating whether pre-ovulatory follicular fluid (FF) levels of selected proteins differ between women who do or do not develop severe...
