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Jorge clinical study: 10-year outcomes of risk-adapted radiotherapy defined by multiparametric MRI for prostate cancer
PurposeTo analyze the 10-year biochemical relapse-free survival (BRFS), locoregional relapse-free survival (LRFS), metastasis-free survival (MFS),...
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Visceral obesity and sarcopenia as predictors of efficacy and hematological toxicity in patients with metastatic breast cancer treated with CDK 4/6 inhibitors
PurposeWe aimed to investigate whether visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and skeletal muscle area (SMA) index are...
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Neoadjuvant treatment with androgen receptor signaling inhibitors prior to radical prostatectomy: a systematic review
ContextThere is an urgent need to develop novel treatment strategies in patients with unfavorable intermediate- and high-risk localized prostate...
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Use of an alfa-lipoic, Methylsulfonylmethane, Boswellia serrata and Bromelain dietary supplement (OPERA®) for aromatase inhibitors-related arthralgia management (AIA): a prospective phase II trial (NCT04161833)
Aromatase Inhibitors (AIs) are recommended for the adjuvant treatment of hormone receptor positive breast cancer in both high-risk pre-menopausal and...
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Risk of renal stone formation in patients treated with luteinising hormone-releasing hormone analogues for prostate cancer: importance of bone metabolism and urine calcium
PurposeTo determine whether androgen blockade produces metabolic changes in urine and increases the risk of calculi after 1 year of treatment.
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Pulmonary benign metastasising leiomyoma: a single-institution case series
BackgroundBenign metastasising leiomyoma (BML) is a rare and often asymptomatic presentation of smooth muscle tumour of uterine origin, occurring...
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Abiraterone acetate plus LHRH therapy versus abiraterone acetate while sparing LHRH therapy in patients with progressive, metastatic and chemotherapy-naïve, castration-resistant prostate cancer (SPARE): study protocol for a randomized controlled trial
BackgroundThe value of continuation of luteinizing hormone-releasing hormone (LHRH) therapy in castration-resistant prostate cancer (CRPC) remains...
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Prostate cancer
Prostate cancer is a complex disease that affects millions of men globally, predominantly in high human development index regions. Patients with...
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HR+/HER2− Metastatic Breast Cancer: Epidemiology, Prescription Patterns, Healthcare Resource Utilisation and Costs from a Large Italian Real-World Database
Background and ObjectiveBreast cancer is the second leading cause of cancer death worldwide. The economic burden of breast cancer is crucial for the...
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Flare on [18F]PSMA-1007 PET/CT after short-term androgen deprivation therapy and its correlation to FDG uptake: possible marker of tumor aggressiveness in treatment-naïve metastatic prostate cancer patients
PurposeShort-term androgen deprivation therapy (ADT) is known to increase heterogeneously prostate-specific membrane antigen (PSMA) expression. This...
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Systematic review of pregnancy and renal outcomes for women with chronic kidney disease receiving assisted reproductive therapy
BackgroundAs awareness around infertility is increasing among patients with chronic kidney disease (CKD), ever more of them are seeking Assisted...
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Changes in taste and smell of food during prostate cancer treatment
PurposeThe present study examined the prevalence of changes in the taste and smell of food among men with advanced prostate cancer who were receiving...
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Upfront metastasis-directed therapy in oligorecurrent prostate cancer does not decrease the time from initiation of androgen deprivation therapy to castration resistance
The aim of the present study was to explore the potential impact of upfront metastases-directed therapy (MDT) in terms of prolongation of...
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The pharmacokinetics of buserelin after intramuscular administration in pigs and cows
BackgroundBuserelin is a luteinizing hormone releasing hormone (LHRH) agonist used for the treatment of hormone-dependent diseases in males and...
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Pilot randomized controlled trial of a program to enhance experience and adherence with adjuvant endocrine therapy among women with non-metastatic breast cancer: 12-month quantitative results
PurposeAdjuvant endocrine therapy (AET) reduces recurrence risk after hormone receptor-positive breast cancer, but non-adherence is common. We...
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Multidisciplinary consensus on the criteria for fertility preservation in cancer patients
Infertility is one of the main sequelae of cancer and its treatment in both children and adults of reproductive age. It is, therefore, essential that...
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Switching from an LHRH Antagonist to an LHRH Agonist: A Case Report of 10 Finnish Patients with Advanced Prostate Cancer
IntroductionLuteinizing hormone-releasing hormone (LHRH) analogues are widely used for the treatment of advanced hormone-dependent prostate cancer....
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The role of the p90 ribosomal S6 kinase family in prostate cancer progression and therapy resistance
Prostate cancer (PCa) is the second most commonly occurring cancer in men, with over a million new cases every year worldwide. Tumor growth and...
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Unexpected tumor response to palliative pelvic radiotherapy in mismatch repair-deficient advanced prostate cancer: a case report
BackgroundMismatch-repair-deficiency resulting in microsatellite instability (MSI) may confer increased radiosensitivity in locally...
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Red clover and lifestyle changes to contrast menopausal symptoms in premenopausal patients with hormone-sensitive breast cancer receiving tamoxifen
PurposeTo determine whether a red clover preparation plus dietary intervention administered to premenopausal women with breast cancer (BC), improves...
