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Gene–gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer
BackgroundAberrant Wnt signalling, regulating cell development and stemness, influences the development of many cancer types. The Aryl hydrocarbon...
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Association of GAB1 gene with asthma susceptibility and the efficacy of inhaled corticosteroids in children
Asthma is a polygenic disease that may onset during childhood. Inhaled corticosteroids (ICS) are the main therapy in asthma, although their efficacy...
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Understanding Environmental Exposures and ADHD: a Pathway Forward
This commentary addresses a series of articles in Prevention Science about environmental causes of attention deficit hyperactivity disorder (ADHD)....
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The effect of disease misclassification on the ability to detect a gene-environment interaction: implications of the specificity of case definitions for research on Gulf War illness
BackgroundSince 1997, research on Gulf War illness (GWI) has predominantly used 3 case definitions—the original Research definition, the CDC...
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Joint Effects Between CDKN2B/P15 Methylation and Environmental Factors on the Susceptibility to Gastric Cancer
BackgroundThe incidence of gastric cancer has long been at a high level in China, seriously affecting the health of Chinese people.
Aims ...
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Prenatal programming of environmental sensitivity
According to several theories, people differ in their sensitivity to environmental influences with some more susceptible than others to both...
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Environmental and parental risk factors for congenital solitary functioning kidney — a case–control study
BackgroundThe etiology of congenital solitary functioning kidney (CSFK) is largely unknown but likely includes various risk factors. We performed a...
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Study protocol of the Berlin Research Initiative for Diagnostics, Genetics and Environmental Factors in Schizophrenia (BRIDGE-S)
BackgroundLarge-scale collaborative efforts in the field of psychiatric genetics have made substantial progress in unraveling the biological...
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Interaction of 5-HTTLPR and SLE disease status on resting-state brain function
BackgroundNeuropsychiatric involvement in systemic lupus erythematosus (SLE) is a common clinical manifestation. In SLE patients, cerebral function...
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Haplotype analysis on association between C-reactive protein gene and susceptibility to type 2 diabetes mellitus in Chinese Han population
AimsWe aimed to evaluate the impact of C-reactive protein (CRP) gene polymorphism, additional gene–gene interaction, and haplotypes on susceptibility...
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Gene–gene and gene-environment interactions on cord blood total IgE in Chinese Han children
BackgroundIL13, IL4, IL4RA, FCER1B and ADRB2 are susceptible genes of asthma and atopy. Our previous study has found gene–gene interactions on...
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Interaction of the pre- and postnatal environment in the maternal immune activation model
Adverse influences during pregnancy are associated with a range of unfavorable outcomes for the develo** offspring. Maternal psychosocial stress,...
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Environmental neuroscience linking exposome to brain structure and function underlying cognition and behavior
Individual differences in human brain structure, function, and behavior can be attributed to genetic variations, environmental exposures, and their...
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Molecular and in silico analyses of SYN III gene variants in autism spectrum disorder
BackgroundDefects in neurotransmission and synaptogenesis are noteworthy in the pathogenesis of ASD. Synapsin III (SYN III) is defined as a synaptic...
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Neurodevelopmental disturbances in schizophrenia: evidence from genetic and environmental factors
Since more than 3 decades, schizophrenia (SZ) has been regarded as a neurodevelopmental disorder. The neurodevelopmental hypothesis proposes that SZ...
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Characterization of early psychosis patients carrying a genetic vulnerability to redox dysregulation: a computational analysis of mechanism-based gene expression profile in fibroblasts
In view of its heterogeneity, schizophrenia needs new diagnostic tools based on mechanistic biomarkers that would allow early detection. Complex...
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Gene regulatory networks in disease and ageing
The precise control of gene expression is required for the maintenance of cellular homeostasis and proper cellular function, and the declining...
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Prenatal exposure to environmental contaminants and cord serum metabolite profiles in future immune-mediated diseases
BackgroundPrenatal exposure to environmental contaminants is a significant health concern because it has the potential to interfere with host...
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Glutathione S-Transferase Gene Associations and Gene-Environment Interactions for Asthma
Purpose of ReviewAsthma is one of the most common chronic inflammatory airway diseases. Airway oxidative stress is defined as an imbalance between...
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Parkinson’s disease and schizophrenia interactomes contain temporally distinct gene clusters underlying comorbid mechanisms and unique disease processes
Genome-wide association studies suggest significant overlaps in Parkinson’s disease (PD) and schizophrenia (SZ) risks, but the underlying mechanisms...
