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A new murine model of giant proximal axonopathy
The aromatic γ-diketone 1,2-diacetylbenzene (1,2-DAB), the putative active metabolite of the organic solvent 1,2-diethylbenzene, forms blue-colored...
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Reproductive toxicity of 2,5-hexanedione in male rats
Background, Aims and Method2,5-Hexanedione is an industrial solvent which causes peripheral neuropathy. In the current study, the effect of...
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Assessment of an electron-impact GC-MS method for organic acids and glycine conjugates in amniotic fluid
Summary : We assessed the reliability of a method designed for common electron-impact GC-MS systems to determine in a single run most organic acids...
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Differential expression of cytochrome P450 enzymes in cultured and intact foetal rat ventral mesencephalon
Genetic susceptibility to toxin action leading to nigral cell degeneration in Parkinson’s disease (PD) may be dictated by the activity of P450...
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Poor metabolization of n-hexane in Parkinson's disease
Although genomic screening studies have identified several genes associated with Parkinson's disease (PD), there is evidence that environmental...
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Genetic polymorphism of the CYP2E1 gene and susceptibility to Parkinson's disease in Taiwanese
Cytochrome P450IIE1 (CYP2E1), an ethanol-inducible cytochrome P450 enzyme, is expressed in the basal ganglia and is probably involved in the...
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Male germ cell death in mouse testes: possible involvement of Fas and Fas ligand
Loss of germ cells is very common during various stages of mammalian spermatogenesis. Although cell death, particularly apoptosis, has been...
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Physiologie de la Barrière Sang-Testicule
There is evidence for the existence of a barrier between the blood and the lumina of the seminiferous tubules, from the uneven coloration of the...
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Role of c-kit in mammalian spermatogenesis
The tyrosine-kinase receptor c-kit and its ligand, stem cell factor (SCF), are essential for the maintenance of primordial germ cells (PGCs) in both...
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Difference in pathogenesis between herpes simplex virus type 1 encephalitis and tick-borne encephalitis demonstrated by means of cerebrospinal fluid markers of glial and neuronal destruction
We determined the extent of neuronal and glial cell destruction in 13 patients with herpes simplex type 1 (HSV-1) encephalitis, 15 patients with...
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A possible association between exposure to n-hexane and parkinsonism
Recently, some case-control studies and case reports have shown an association between solvent exposure and parkinsonisms. We present a 55-year-old...
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Influence of neurotoxins and oxidative stress on the onset and progression of Parkinson’s disease
It is generally accepted that progressive, irreversible and regionally specific neurodegeneration and the presence of Lewy bodies are the essential...
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Distal axonopathy does not occur without neurofilament accumulation in γ-diketone neuropathy: comparative studies of normal and neurofilament-deficient quail
The neurotoxic effects caused by chronic exposure to 2,5-hexanedione (2,5-HD) were investigated in normal and neurofilament (NF)-deficient quail...
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Effect of Acrylamide on Neurological Recovery Following Spinal Cord Injury in Rats
Acrylamide (ACR) is a cumulative neurotoxin which causes axonal degeneration in animals and man. Industrial workers exposed to ACR have been...
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Indications and outcome of liver transplantation in tyrosinaemia type 1
A retrospective analysis was performed on 17 patients presenting with tyrosinaemia type 1 (TT1) between 1989–1997; 7 pre 1992 prior to the...
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Effect of aging on spontaneous and induced mouse testicular germ cell apoptosis
The purpose of this study was to determine whether apoptotic cell death of mouse testicular germ cells varies with increased age, or with exposure to...
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Tyrosinaemia type I and NTBC (2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione)
In tyrosinaemia type I (McKusick 276700), fatal liver disease results either because of liver failure during infancy or early childhood or because of...