References
Audinat E, Gahwiler BH, Knopfel T (1992) Excitatory synaptic potentials in neurons of the deep nuclei in olivocerebellar slice cultures. Neuroscience 49:903–911
Cardile V, Pavone A, Gulino R, Renis M, Scifo C, Perciavalle V (2003) Expression of brain-derived neurotrophic factor (BDNF) and inducible nitric oxide synthase (iNOS) in rat astrocyte cultures treated with levetiracetam. Brain Res 976:227–233
Estevez AG, Spear N, Manuel SM, Radi L, Barbeito L, Beckman JS (1998) Role of endogenous nitric oxide and peroxynitrite formation in the survival and death of motor neurons in culture. In: Mize R, Fredlander M (eds) Progress in Brain Res, vol 118, Elsevier, Amsterdam, pp 269–280
Garthwaite J, Brodbelt AR (1989) Glutamate as the principal mossy fibre transmitter in rat cerebellum: pharmacological evidence. Eur J Neurosci 2:177–180
Hernandez-Viadel M, Montoliu C, Monfort P, Canales JJ, Erceg S, Rowan M, Ceccatelli S, Felipo V (2003) Chronic exposure to 2,5-hexanedione impairs the glutamate-nitric oxidecyclic GMP pathway in cerebellar neurons in culture and in rat brain in vivo. Neurochem Int 42:525–533
Kendrick KM, Guevara-Guzman R, de la Riva C, Christensen J, Ostergaard K, Emson PC (1996) NMDA and kainiteevoked release of nitric oxide and classical transmitters in the rat striatum: in vivo evidence that nitric oxide may play a neuroprotective role. Eur J Neurosci 8:2619–2634
Klitgaard H, Pitkanen A (2003) Antiepileptogenesis, neuroprotection, and disease modification in the treatment of epilepsy: focus on levetiracetam. Epileptic Disord 5:S9–S16
Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B (2004) The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci USA 101:9861–9866
Micheva KD, Holz RW, Smith SJ (2001) Regulation of presynaptic phosphatidylinositol 4,5-biphosphate by neuronal activity. J Cell Biol 23:355–368
Paxinos G, Watson C (1986) The rat brain in stereotactic coordinates. Academic Press, New York
Sequeira SM, Malva JO, Carvalho AP, Carvahlo CM (2001) Presynaptic NMDA receptor activation inhibits neurotransmitter release through nitric oxide formation in rat hippocampal nerve terminals. Brain Res Mol Brain Res 89:111–118
Snider BJ, Choi J, Turetsky DM, Canzoniero LM, Sensi LM, Sheline CT, Wang X, Yu SP, Choi DW (2000) Nitric oxide reduces Ca++ and Zn++ influx through voltage-gated Ca++ channels and reduces Zn++ neurotoxicity. Neuroscience 100:651–661
Wall MJ (2003) Endogenous nitric oxide modulates GABAergic transmission to granule cells in adult rat cerebellum. Eur J Neurosci 18:869–878
Yamada K, Nabeshima T (1997) Two pathways of nitric oxide production through glutamate receptors in the rat cerebellum in vivo. Neurosci Res 28:93–102
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dagonnier, M., Laute, MA., Pandolfo, M. et al. Effects of levetiracetam on the production of nitric oxide. J Neurol 252, 727–730 (2005). https://doi.org/10.1007/s00415-005-0726-y
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00415-005-0726-y