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A Review of Diagnostic Methods for Invasive Fungal Diseases: Challenges and Perspectives
Invasive fungal diseases are associated with a high morbidity and mortality, particularly in the context of immunosuppression. Diagnosis of invasive...
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A state of the art review on optimal practices to prevent, recognize, and manage complications associated with intravascular devices in the critically ill
Intravascular catheters are inserted into almost all critically ill patients. This review provides up-to-date insight into available knowledge on...
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T cells from patients with Candida sepsis display a suppressive immunophenotype
BackgroundDespite appropriate therapy, Candida bloodstream infections are associated with a mortality rate of approximately 40 %. In animal models,...
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Echinocandin Resistance in Candida Species: a Review of Recent Developments
The echinocandins are important agents for the treatment of invasive fungal infections, especially those caused by Candida species. However, as with...
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Initial therapeutic strategy of invasive candidiasis for intensive care unit patients: a retrospective analysis from the China-SCAN study
BackgroundTo investigate the impact of initial antifungal therapeutic strategies on the prognosis of invasive Candida infections (ICIs) in intensive...
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Prevention and treatment of neonatal nosocomial infections
Nosocomial or hospital acquired infections threaten the survival and neurodevelopmental outcomes of infants admitted to the neonatal intensive care...
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Comparison of Efficacy and Safety of Caspofungin Versus Micafungin in Pediatric Allogeneic Stem Cell Transplant Recipients: A Retrospective Analysis
IntroductionThe high morbidity and mortality associated with invasive fungal infections (IFIs) provide the rationale for antifungal prophylaxis in...
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Abdominal Sepsis
Abdominal infections are an important challenge for the intensive care physician. In an era of increasing antimicrobial resistance, selecting the...
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Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy
Invasive fungal infections, particularly those caused by Candida species, are not uncommon in critically ill patients and are associated with...
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Empiric treatment against invasive fungal diseases in febrile neutropenic patients: a systematic review and network meta-analysis
BackgroundThe most optimal antifungal agent for empiric treatment of invasive fungal diseases (IFDs) in febrile neutropenia is controversial. Our...
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Characteristics and risk factors for 28-day mortality of hospital acquired fungemias in ICUs: data from the EUROBACT study
BackgroundTo characterize and identify prognostic factors for 28-day mortality among patients with hospital-acquired fungemia (HAF) in the Intensive...
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Multimodal imaging of refractory Candida chorioretinitis progressing to endogenous endophthalmitis
BackgroundEndogenous fungal endophthalmitis is a serious vision-threatening condition that occurs in immunosuppressed patients with candidemia.
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