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Phenotypic and mutational spectrum of 17 Chinese patients with Menkes Disease
BackgroundMenkes Disease (MD) is a fatal X-linked recessive disorder caused by mutations in the ATP7A gene. Severe cases typically die before the age...
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Guideline “Parkinson’s disease” of the German Society of Neurology (Deutsche Gesellschaft für Neurologie): concepts of care
IntroductionIn 2023, the German Society of Neurology published a new guideline on Parkinson’s disease. An important section dealt with PD care...
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Elevated plasma neurofilament light was associated with multi-modal neuroimaging features in Alzheimer’s disease signature regions and predicted future tau deposition
BackgroundNeurofilament Light (NfL) is a biomarker for early neurodegeneration in Alzheimer’s disease (AD). This study aims to examine the...
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Targeting Neurotransmitter Systems in Bipolar Disorder: A comprehensive Review of novel pharmacological approaches
Purpose of ReviewTo critically assess the efficacy of novel pharmacological interventions in managing manic or hypomanic episodes in adult patients...
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Successful treatment with efgartigimod as an add-on therapy in acute attack of anti-AQP4 antibody-positive NMOSD: a case report
BackgroundNeuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune demyelinating disease characterized by recurrent myelitis and optic...
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Clinical spreading of muscle weakness in amyotrophic lateral sclerosis (ALS): a study in 910 patients
BackgroundNeuroanatomical staging of sporadic amyotrophic lateral sclerosis (ALS) indicates that neurodegeneration may spread corticofugally.
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Plasma alpha B crystallin as potential biomarker for predicting pre-operative seizures in glioma
PurposeGlioma-associated epilepsy affects a significant proportion of glioma patients, contributing to disease progression and diminished survival...
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Single-centre real-life observational study on mortality and outcomes: decompressive craniectomy and brain death in traumatic brain injury, haemorrhage, and other cerebral diseases
BackgroundDecompressive hemicraniectomy (DHC) is used after severe brain damages with elevated, refractory intracranial pressure (ICP). In a non...
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Radiosurgical thalamotomy for the management of tremors: a systematic review and meta-analysis
Medical treatment for tremors may include beta-blockers, primidone, dopaminergic, and anticholinergic drugs but it frequently leads to...
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Fatigue in multiple sclerosis: can we measure it and can we treat it?
Fatigue is a common and debilitating symptom in multiple sclerosis (MS). However, after over 100 years of inquiry its definition, measurement and...
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Sex-dependent associations of serum BDNF, glycolipid metabolism and cognitive impairments in Parkinson’s disease with depression: a comprehensive analysis
Brain-derived neurotrophic factor (BDNF) and glycolipid metabolism have been implicated in cognitive impairments and depression among Parkinson’s...
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Monotherapy with infusion therapies – useful or not?
Infusion pump-based therapies are an effective treatment option for patients with advanced Parkinson´s disease. Achieving monotherapy with...
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Rate of abnormalities in quantitative MR neuroimaging of persons with chronic traumatic brain injury
BackgroundMild traumatic brain injury (mTBI) can result in lasting brain damage that is often too subtle to detect by qualitative visual inspection...
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Latinx Sexual Minority Women and Substance Use: a Sco** Review and Call to Action
Purpose of ReviewLatinx sexual minority women (LSMW) remain a greatly understudied population, likely due to the intersectional invisibility they...
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Multicenter evaluation of mechanical thrombectomy for distal medium vessel occlusions with National Institute of Health Stroke Scale Scores ≥ 6 and ≤ 6
BackgroundWhile mechanical thrombectomy is considered standard of care for large vessel occlusions, scientific evidence to support treatment for...
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Evaluation of 3D T1-weighted spoiled gradient echo MR image quality using artificial intelligence image reconstruction techniques in the pediatric brain
PurposeTo assess image quality and diagnostic confidence of 3D T1-weighted spoiled gradient echo (SPGR) MRI using artificial intelligence (AI)...
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AChR-seropositive myasthenia gravis in muscular dystrophy: diagnostic pitfalls and clinical management challenges
The co-occurrence of genetic myopathies with myasthenia gravis (MG) is extremely rare, however a few studies have been reported. We aim to explore...
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The effect of transcranial magnetic stimulation on cognitive function in post-stroke patients: a systematic review and meta-analysis
Background and ObjectiveTranscranial magnetic stimulation (TMS) is considered as a promising treatment option for post-stroke cognitive impairment...
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Atypical and anaplastic meningiomas in the later decades of life: A national cancer database analysis
PurposeWe conducted a National Cancer Database (NCDB) study to investigate the epidemiological characteristics and identify predictors of outcomes...
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Trans-temporal trans-choroidal resection of thalamic and thalamopeduncular tumors: how I do it
BackgroundSurgical resection is the cornerstone of treatment for low-grade tumors, albeit total excision is beneficial. As the thalamus is...
