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Atypical and anaplastic meningiomas in the later decades of life: A national cancer database analysis

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Abstract

Purpose

We conducted a National Cancer Database (NCDB) study to investigate the epidemiological characteristics and identify predictors of outcomes associated with geriatric meningiomas.

Methods

The NCDB was queried for adults aged 60–89 years diagnosed between 2010 and 2017 with grade 2 and 3 meningiomas. The patients were classified into three age groups based on their age: 60–69 (hexagenarians), 70–79 (septuagenarians), and 80–89 (octogenarians). The log-rank test was utilized to compare the differences in overall survival (OS). Univariate and multivariate Cox proportional hazards regressions were used to evaluate the mortality risk associated with various patient and disease parameters.

Results

A total of 6585 patients were identified. Hexagenerians were the most common age group (49.8%), with the majority of meningiomas being classified as grade 2 (89.5%). The incidence of high-grade meningiomas increased in all age groups during the study period. Advanced age, male sex, black race, lower socioeconomic status, Charlson-Deyo score ≥ 2, and higher tumor grade were independent factors of poor survival. Among the modes of treatment, the extent of surgical resection, adjuvant radiotherapy, and treatment at a noncommunity cancer program were linked with better outcomes.

Conclusion

In geriatric patients with high-grade meningiomas, the greater extent of surgical resection and radiotherapy are associated with improved survival. However, the management and outcome of geriatric patients with higher-grade meningiomas are also associated with several socioeconomic factors.

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Data availability

Restrictions apply to the availability of these data. Data were obtained from the NCDB, a prospectively maintained repository collaboratively developed by the Commission on Cancer (CoC) of the American College of Surgeons and the American Cancer Society.

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The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Neurosurgery, Mount Sinai Health System, New York, NY, USA

    Mert Karabacak, Rui Feng, Raj Shrivastava & Konstantinos Margetis

  2. Department of Neurosurgery, School of Medicine, University of Ioannina, Ioannina, Greece

    Marios Lampros

  3. Dietrich College of Humanities and Social Sciences, Carnegie Mellon University, Pittsburgh, PA, USA

    Olga Mavridis

  4. School of Medicine, SUNY Downstate Health Sciences University, New York, NY, USA

    Pemla Jagtiani

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Contributions

Conceptualization, MK, and KM.; Methodology, MK, and KM; Software, MK; Formal Analysis, MK; Data Curation, MK; Writing – Original Draft Preparation, ML, MK, OM, and PJ; Writing – Review & Editing, MK, RS, and KM; Visualization, MK; Supervision, KM; Project Administration, MK, and KM.

Corresponding author

Correspondence to Konstantinos Margetis.

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The study was deemed exempt by the Icahn School of Medicine at Mount Sinai's institutional review board.

Statement for NCDB

The Commission on Cancer (CoC) of the American College of Surgeons and the American Cancer Society is the source of the data used herein; none of these institutions verified and are not responsible for the statistical validity of the data analysis or the conclusions derived by the authors.

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The authors have no relevant financial or non-financial interests to disclose.

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Karabacak, M., Lampros, M., Mavridis, O. et al. Atypical and anaplastic meningiomas in the later decades of life: A national cancer database analysis. Acta Neurochir 166, 282 (2024). https://doi.org/10.1007/s00701-024-06157-0

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