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The Causal Relationship between Genetically Predicted Biological Aging, Alzheimer’s Disease and Cognitive Function: A Mendelian Randomisation Study
Aging is one of the most important risk factors for Alzheimer’s disease (AD). Biological aging is a better indicator of the body’s functional state...
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Nusinersen effectiveness and safety in pediatric patients with 5q-spinal muscular atrophy: a multi-center disease registry in China
ObjectiveTo evaluate the effectiveness and safety of nusinersen for the treatment of 5q-spinal muscular atrophy (SMA) among Chinese pediatric...
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Emotional awareness in patients with amyotrophic lateral sclerosis
IntroductionIt has been recently acknowledged that deficits in experiencing and processing one’s own emotions, also termed alexithymia, may possibly...
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Association of Dynamic Trajectories of Time-Series Data and Life-Threatening Mass Effect in Large Middle Cerebral Artery Stroke
BackgroundLife-threatening, space-occupying mass effect due to cerebral edema and/or hemorrhagic transformation is an early complication of patients...
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External validation of clinical risk prediction score for elderly treated with endovascular thrombectomy
Background and aimThe thrombectomy in the elderly prediction score (TERPS) for functional outcome after anterior circulation endovascular therapy...
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Prevalence and 3-month follow-up of cerebrovascular MRI markers in hospitalized COVID-19 patients: the CORONIS study
PurposeTo investigate the prevalence of cerebrovascular MRI markers in unselected patients hospitalized for COVID-19 (Coronavirus disease 2019), we...
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A Long-Term Safety and Tolerability Study of TV-46000 for Subcutaneous Use in Patients with Schizophrenia: A Phase 3, Randomized, Double-Blinded Clinical Trial
BackgroundTV-46000 is a long-acting subcutaneous antipsychotic (LASCA) formulation of risperidone that is approved by the United States Food and Drug...
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The importance of sleep for the develo** brain
Purpose of reviewThis paper summarizes recent research regarding the possible contribution of sleep to brain development. Major milestones in brain...
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Factors associated with a placebo effect in Parkinson’s disease in clinical trials: a meta-analysis
ObjectivesOutcomes of clinical trials of treatment in patients with Parkinson’s disease (PD) may be influenced by placebo effects. The aim of this...
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A Statistical Framework for Assessing the Relationship between Biomarkers and Clinical Endpoints in Alzheimer’s Disease
Changes in biomarker levels of Alzheimer’s disease (AD) reflect underlying pathophysiological changes in the brain and can provide evidence of direct...
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Modulatory Effect of Blood LDL Cholesterol on the Association between Cerebral Aβ and Tau Deposition in Older Adults
BackgroundThis study investigates the synergistic relationship between blood low-density lipoprotein cholesterol (LDL-C) and cerebral beta-amyloid...
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(Auto‑)Immunität bei fokaler Epilepsie: Mechanismen (auto‑)immun-inflammatorischer epileptogener Neurodegeneration
ObjectiveWhile the neuronal mechanisms of epileptic hyperexcitability (HE) have been studied in detail, recent findings suggest that extraneuronal,...
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Population-Based Analysis of 6534 Seizure Emergency Cases from Emergency Medical Services Data
IntroductionSeizures are common reasons to call an ambulance, and this study aims to analyze the burden of seizures in the prehospital setting based...
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The neurocognitive and neuropsychiatric manifestations of Susac syndrome: a brief review of the literature and future directions
Encephalopathy is part of the clinical triad of Susac syndrome, but a detailed understanding of the neurocognitive and neuropsychiatric profile of...
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Approaches to supratentorial brain tumours in children
The differential diagnosis of supratentorial brain tumours in children can be challenging, especially considering the recent changes to the WHO...
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Unveiling Potential Biomarkers in Cerebrospinal Fluid for Amyloid Pathological Positivity in Non-Demented Individuals
BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta (Aβ) plaque accumulation and...
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Immunologische Grundlagen neurologischer Erkrankungen
BackgroundNeurodegenerative diseases represent an increasing challenge in ageing societies, as only limited treatment options are currently available.
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