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Straight intramedullary MultiLoc nails for displaced proximal humeral fractures: health status, radiographic results, clinical outcome, and complications
BackgroundThe treatment of the displaced proximal humerus fractures (PHF) still facing a lot of unsolved problems. The aim of this study was to...
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Longitudinal analysis on inflammatory markers and frailty progression: based on the English longitudinal study of aging
PurposeFrailty is a common health state that is closely linked to adverse health outcomes in aging society. Although many inflammatory biomarkers...
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Breast lesions on MRI in mass and non-mass enhancement: Kaiser score and modified Kaiser score + for readers of variable experience
ObjectivesTo compare the diagnostic performance of three readers using BI-RADS and Kaiser score (KS) based on mass and non-mass enhancement (NME)...
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Distinctive protein expression in elderly livers in a Sprague–Dawley rat model of normothermic ex vivo liver machine perfusion
BackgroundLiver grafts are frequently declined due to high donor age or age mismatch with the recipient. To improve the outcome of marginal grafts,...
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Incompatibility of the short-acting benzodiazepine remimazolam with common perioperative medication
BackgroundRemimazolam is a relatively new benzodiazepine with growing use in procedural sedation and general anaesthesia. Initiated by case reports,...
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A double CYP27A1 gene mutation in spinal cerebrotendinous xanthomatosis in a patient presenting with spastic gait: a case report
BackgroundCerebrotendinous xanthomatosis (CTX, OMIM #213700) is a rare inherited metabolic disease caused by the mutation in the CYP27A1 gene....
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Optimizing coronary CT angiography quality with motion-compensated reconstruction for second-generation dual-layer spectral detector CT
ObjectivesTo investigate the effect of motion-compensated reconstruction (MCR) algorithm on improving the image quality of coronary computed...
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Immunohistochemistry staining of Eag1 and p16/Ki-67 can help improve the management of patients with cervical intraepithelial Neoplasia after cold knife conversion
BackgroundImmunohistochemistry (IHC) is widely used in the management of patients with cervical intraepithelial neoplasia (CIN) but still has many...
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Impact of the ActTeens Program on physical activity and fitness in adolescents: a cluster randomized controlled trial
BackgroundThe aim of our study was to evaluate the impact of the ActTeens Program on physical activity and health-related physical fitness among...
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Self-assembled nanoparticles of costunolide and glycyrrhizic acid for enhanced ulcerative colitis treatment
Ulcerative colitis (UC) is a persistent inflammatory condition that specifically targets the colon and rectum. Existing therapies fail to adequately...
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The RNA helicases DDX19A/B modulate selinexor sensitivity by regulating MCL1 mRNA nuclear export in leukemia cells
Selinexor, a first-in-class exportin1 (XPO1) inhibitor, is an attractive anti-tumor agent because of its unique mechanisms of action; however, its...
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Integrated network pharmacology and metabolomics to reveal the mechanism of Pinellia ternata inhibiting non-small cell lung cancer cells
Lung cancer is a malignant tumor with highly heterogeneous characteristics. A classic Chinese medicine, Pinellia ternata (PT), was shown to exert...
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Cost-effectiveness analysis of amivantamab plus chemotherapy for non-small cell lung cancer patients with epidermal growth factor receptor exon 20 insertions in the United States
BackgroundAlthough amivantamab has shown clinical benefits for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor...
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Controversy between biopsy and risk in children with proteinuria: is there a paradigm war?
BackgroundProteinuria is a prevalent symptom of pediatric nephrology, while kidney biopsy remains the gold standard for kidney tissue analysis, and...
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Causal impact of statins on susceptibility to osteoarthritis: insights from a two-sample Mendelian randomization analysis
BackgroundOsteoarthritis is a widely prevalent cause of pain and disability among older adults. It is an incurable condition, and most treatments are...
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Age-related effects on absolute and relative isokinetic knee extensor strength in community-dwelling older men and women at a French geriatric day hospital
PurposeIsokinetic knee extensor strength is poorly evaluated in geriatric day hospitals (GDHs), despite its potential functional significance...
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The impact of diet, exercise, and sleep on Helicobacter pylori infection with different occupations: a cross-sectional study
BackgroundAssociations between Helicobacter pylori infection and lifestyle factors vary greatly by geographic location. This study aims to evaluate...
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Do-not-attempt-resuscitation decision making: physicians’ recommendations differ from the GO-FAR score predictions
Background and aimIn-hospital cardiac arrest (IHCA) is a major cause of mortality globally, and over 50% of the survivors will require institutional...
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Momelotinib versus Continued Ruxolitinib or Best Available Therapy in JAK Inhibitor-Experienced Patients with Myelofibrosis and Anemia: Subgroup Analysis of SIMPLIFY-2
IntroductionSome Janus kinase (JAK) inhibitors such as ruxolitinib and fedratinib do not address and may worsen anemia in patients with...
