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Racial and ethnic socioenvironmental inequity and neuroimaging in psychiatry: a brief review of the past and recommendations for the future
Neuroimaging is a major tool that holds immense translational potential for understanding psychiatric disorder phenomenology and treatment. However,...
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NIMH perspectives on future directions in neuroimaging for mental health
NIMH’s mission is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for...
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Validation of a non-food or water motivated effort-based foraging task as a measure of motivational state in male mice
Disorders of motivation such as apathy syndrome are highly prevalent across neurological disorders but do not yet have an agreed treatment approach....
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Ketamine induced synaptic plasticity operates independently of long-term potentiation
Synaptic plasticity occurs via multiple mechanisms to regulate synaptic efficacy. Homeostatic and Hebbian plasticity are two such mechanisms by which...
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Identifying the role of (dis)inhibition in the vicious cycle of substance use through ecological momentary assessment and resting-state fMRI
Functional inhibition is known to improve treatment outcomes in substance use disorder (SUD), potentially through craving management enabled by...
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Chronic post-COVID neuropsychiatric symptoms persisting beyond one year from infection: a case-control study and network analysis
Our study aims to delineate the phenotypes of chronic neuropsychiatric symptoms among adult subjects recovering from their first COVID that occurred...
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Negative emotionality shapes the modulatory effects of ketamine and lamotrigine in subregions of the anterior cingulate cortex
Neuroimaging studies have identified the anterior cingulate cortex (ACC) as one of the major targets of ketamine in the human brain, which may be...
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Irritability in young people with copy number variants associated with neurodevelopmental disorders (ND-CNVs)
A range of rare mutations involving micro-deletion or -duplication of genetic material (copy number variants (CNVs)) have been associated with high...
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A novel blood-based epigenetic biosignature in first-episode schizophrenia patients through automated machine learning
Schizophrenia (SCZ) is a chronic, severe, and complex psychiatric disorder that affects all aspects of personal functioning. While SCZ has a very...
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The single-cell opioid responses in the context of HIV (SCORCH) consortium
Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with...
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Transmissible long-term neuroprotective and pro-cognitive effects of 1–42 beta-amyloid with A2T icelandic mutation in an Alzheimer’s disease mouse model
The amyloid cascade hypothesis assumes that the development of Alzheimer’s disease (AD) is driven by a self-perpetuating cycle, in which β-amyloid...
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Extinction training suppresses activity of fear memory ensembles across the hippocampus and alters transcriptomes of fear-encoding cells
Contextual fear conditioning has been shown to activate a set of “fear ensemble” cells in the hippocampal dentate gyrus (DG) whose reactivation is...
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Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility
Impaired behavioural flexibility is a core feature of neuropsychiatric disorders and is associated with underlying dysfunction of fronto-striatal...
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Shared and unique alterations of large-scale network connectivity in drug-free adolescent-onset and adult-onset major depressive disorder
Differences in clinical manifestations and biological underpinnings between Major Depressive Disorder (MDD) onset during adolescence and adulthood...
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Decoding the inflammatory signature of the major depressive episode: insights from peripheral immunophenoty** in active and remitted condition, a case–control study
Depression is a prevalent and incapacitating condition with a significant impact on global morbidity and mortality. Although the immune system’s role...
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Neuropsychobiology of fear-induced bradycardia in humans: progress and pitfalls
In the last century, the paradigm of fear conditioning has greatly evolved in a variety of scientific fields. The techniques, protocols, and analysis...
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Differential methylation of OPRK1 in borderline personality disorder is associated with childhood trauma
According to a growing body of neurobiological evidence, the core symptoms of borderline personality disorder (BPD) may be linked to an opioidergic...
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Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations
Coffee is one of the most widely consumed beverages. We performed a genome-wide association study ( GWAS ) of coffee intake in US-based 23andMe...
