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Dequalinium-Mediated Mitochondria-Targeting Drug Liposomes for the Treatment of Drug-Resistant Lung Cancer
The liposomes are useful drug carriers that are able to improve the physicochemical property and targeted ability of drugs. Lonidamine has shown a...
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One-pot, degradable, silica nanocarriers with encapsulated oligonucleotides for mitochondrial specific targeting
Mutations in nuclear and mitochondrial genes are responsible for severe chronic disorders such as mitochondrial myopathies. Gene therapy using...
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Oral mitochondrial transplantation using nanomotors to treat ischaemic heart disease
Mitochondrial transplantation is an important therapeutic strategy for restoring energy supply in patients with ischaemic heart disease (IHD);...
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RNA sequencing-based optimization of biological lipid droplets for sonodynamic therapy to reverse tumor hypoxia and elicit robust immune response
Mitochondria-targeted sonodynamic therapy (SDT) is a promising strategy to inhibit tumor growth and activate the anti-tumor immune responses....
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Nano-STING agonist-decorated microrobots boost innate and adaptive anti-tumor immunity
Activating the cyclic guanosine monophosphate-adenosine monophosphate synthase/stimulator of interferon genes (cGAS/STING) signaling has emerged as a...
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Mitochondria-targeting theranostics
BackgroundInterest in subcellular organelle-targeting theranostics is substantially increasing due to the significance of subcellular...
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Charge-reversible crosslinked nanoparticle for pro-apoptotic peptide delivery and synergistic photodynamic cancer therapy
Although anti-cancer nanotherapeutics have made breakthroughs, many remain clinically unsatisfactory due to limited delivery efficiency and...
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Enhanced porphyrin-based fluorescence imaging-guided photodynamic/photothermal synergistic cancer therapy by mitochondrial targeting
Mitochondria are the power plants of the cell and play key roles in activating the apoptotic pathway in cancer cells, which are readily susceptible...
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Nitrogen and sulfur co-doped carbon nanodots in living EA.hy926 and A549 cells: oxidative stress effect and mitochondria targeting
Carbon nanodots (CNDs) have been studied in the field of biomedicine, such as drug delivery, bioimaging and theragnosis because of their superior...
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Organelle-level precision with next-generation targeting technologies
Intracellular organelles are subsystems within a cell, whose activity and chemical composition reflect the metabolic state of live cells. Alterations...
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Dequalinium-Mediated Mitochondria-Targeting Drug Liposomes for the Treatment of Drug-Resistant Lung Cancer
The liposomes are useful drug carriers that are able to improve the physicochemical property and targeted ability of drugs. Lonidamine has shown a...
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pH-activatable lactam-stapled peptide-based nanoassemblies for enhanced chemo-photothermal therapy
The practical application of nanomedicines for cancer therapy is generally hampered by their compromised tumor accumulation and transmembrane...
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Liposome trade-off strategy in mitochondria-targeted NIR-cyanine: balancing blood circulation and cell retention for enhanced anti-tumor phototherapy in vivo
Cancer phototheranostics involving optical imaging-guided photodynamic therapy (PDT) and photothermal therapy (PTT) is a localized noninvasive...
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pH-triggered cancer-targeting polymers: From extracellular accumulation to intracellular release
Stimuli-responsive polymers are promising to achieve targeted delivery, improved stability during circulation, and controlled release of therapeutic...
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Preparation and Characterization of pH Sensitive Drug Liposomes
There are multiple physiological and pathological barriers in cancer therapy faced by anticancer drug on the route from the injection site to the...
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Photoacoustic-immune therapy with a multi-purpose black phosphorus-based nanoparticle
Effective therapeutic strategies to precisely eradicate primary tumors with minimal side effects on normal tissue, inhibit metastases, and prevent...
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BODIPY: A Unique Dye for Versatile Optical Applications
During the last three decades, the boradipyrromethene (BODIPY) dyes are established as one of the most versatile class of organic dyes for various...
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Self-shrinking supramolecular nanoparticles syndicate energy suppression and NIR-II mild photothermal amplification of mitochondrial oxidative stress for breast cancer therapy
Photothermal therapy (PTT) may lead to healthy tissue damage, tumor metastasis, and recurrence, which makes mild photothermal therapy (mild PTT)...
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Precise visualization and ROS-dependent photodynamic therapy of colorectal cancer with a novel mitochondrial viscosity photosensitive fluorescent probe
BackgroundColorectal cancer (CRC) is a prominent global cancer with high mortality rates among human beings. Efficient diagnosis and treatment have...
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In situ self-assembly for cancer therapy and imaging
In situ self-assembly — the in situ formation of complex materials via biochemical reactions of monomers — has enhanced the efficacy of drug delivery...
