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Highly flexible and controllable hierarchical MOF membrane for efficient drug release
An active wound dressing that is biomechanically and biochemically effective is essential for wound care and skin tissue regeneration. Despite its...
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Dual gatekeepers-modified dendritic mesoporous silica nanoparticles for controlled drug release
It is urgent to develop functional nanocarriers for targeted drug therapy of cancer. This work developed a smart drug controlled release system based...
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Photothermally modulated drug release kinetics for pH and thermo-responsive hydrogel system
Injectable hydrogel systems to achieve controlled drug release for localized chemotherapy are emerging modality for cancer therapy. Here, an...
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Graphene oxide-templated biomineralization nanosystem enables multi-drug loading and controllable release
As a promising antitumor strategy, combination oncotherapy can achieve better therapeutic efficacy. However, given the different properties of drugs,...
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Surface-modified gold-coated superparamagnetic iron oxide nanoparticles promoting light-controlled drug release
The main translational barrier of neuroprotective drugs such as retinoic acid (RA) is the lack of targeted delivery to the specified brain region and...
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Controlled Release Systems
Drugs are bioactive agents used to treat or prevent diseases and illnesses through chemical action in the body. In order for a drug to be effective,...
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Size-transformable nanoparticles with sequentially triggered drug release and enhanced penetration for anticancer therapy
There are several limitations to the application of nanoparticles in the treatment of cancer, including their low drug loading, poor colloidal...
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Enhanced boron neutron capture therapy (BNCT) through controlled drug release via boron-loaded nanofiber mats
Boron neutron capture therapy (BNCT) is a novel binary therapy combining boron targeted drugs and neutron irradiation, which can selectively and...
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Photothermal switch of drug release from polydopamine-modified nanosheets
Colorectal cancer, which is difficult to treat and has a high recurrence rate, is a challenging target. Here, we propose a novel multi-layered...
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pH-responsive drug release from positively charged mesoporous silica nanoparticles and their potential for anticancer drug delivery
Mesoporous silica nanoparticles (MSNs) have shown incredible potential for drug delivery owing to their orderly mesoporous structure, high surface...
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Concentration-dependent bacterial cellulose patches: a strategy for modulating the drug release beyond the modifications of the native cellulose hydrogel
Considering the increasing interest in the need-specific drug release profiles in transdermal patches, the understanding of the complex relationship...
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Synergistic effect of cerium and structure directing agent on drug release behavior and kinetics
This work was mainly aimed at the study of the dual effect of cerium and structure directing agent template concentration, on vancomycin release...
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Drug release properties of amphoteric HES/p(AETAC-co-IA) hydrogels decorated with gold nanoparticles
In this study, amphoteric hydroxyethyl starch/p([2(acryloyloxy)ethyl]trimethylammonium chloride-co-itaconic acid (HES/p(AETAC-co-IA) hydrogels...
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Structural and Interfacial Effects on Drug Release Kinetics of Liquid-Based Fibrous Catheter
Catheterization is indispensable in the field of modern medicine. However, catheter-related thrombosis and infections almost inevitably occur during...
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Porous design of molecularly imprinted polymers for improved drug loading and organized release properties
AbstractMolecular imprinting materials can successfully improve the efficacy and safety of drugs, thus showing good potential in the field of drug...
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Theranostic nanoparticles ZIF-8@ICG for pH/NIR-responsive drug-release and NIR-guided chemo-phototherapy against non-small-cell lung cancer
This study leverages nanotechnology by encapsulating indocyanine green (ICG) and paclitaxel (Tax) using zeolitic imidazolate frameworks-8 (ZIF-8) as...
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Redox-responsive degradable microgel modified with superparamagnetic nanoparticles exhibiting controlled, hyperthermia-enhanced drug release
A novel degradable microgel based on poly( N -isopropylacrylamide) (pNIPA) cross-linked with N , N ’-bisacryloylcystine (BISS) and containing...
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Fundamentals of Drug Delivery
Drug delivery systems have the potential of deciding the efficiency of a therapeutic agent. The potential of a drug is often limited by the lack of...
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Shell-sheddable antibiotic nanohybrid through drug-mediated surface-initiated polymerization: an overcoat approach for modulated burst release
AbstractAntibiotic-impregnated bioactive therapeutic biomaterials are highly demanding due to the risk of infection associated with musculoskeletal...
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Novel multifunctional bioactive glass incorporated alginate/poly(amidoamine) hydrogels with controlled drug release for cartilage tissue regeneration
Tissue engineering faces an intriguing challenge in creating biomaterials for cartilage repair. Within the category of biopolymeric scaffolds,...
