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Fundamentals of Drug Delivery

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Nanomaterials for Drug Delivery and Neurological Diseases Management

Part of the book series: Smart Nanomaterials Technology ((SNT))

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Abstract

Drug delivery systems have the potential of deciding the efficiency of a therapeutic agent. The potential of a drug is often limited by the lack of effective delivery systems and therefore, past few years have seen tremendous upsurge in the research oriented towards development of different systems for the drug delivery systems. From the development of orally administered pills to nanoparticles-based delivery systems, the technologies for drug deliveries have come a long way. The first big success is the development of biological, chemical and physical means that are adopted to alter the pharmacokinetic properties of the drug to exhibit the desired pharmacological effect and remove undesirable physiochemical properties. Development in drug delivery systems can be described through different phases which are described as different generations of the drug delivery system. Sustained gradual release is the first generation of control drug release practice in which a drug is packed in a capsule or in the form of a capsule that releases drug with it when mixed with water in the stomach. On the other hand, targeted drug delivery system is a special system of drug delivery in which the drug is selectively targeted only to the site of action/absorption and not to the non-target tissues, cells or organ. This chapter provides a glimpse of various physiochemical and biological barriers that restrict effective drug delivery and the techniques adopted to overcome these barriers for effective drug delivery.

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Authors and Affiliations

  1. University Institute of Biotechnology, Chandigarh University, Gharuan, Mohali, Punjab, 140413, India

    Shubham Kumar,  Nidhi, Babita Thakur, Vagish Dwibedi & Jasdeep Singh

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  1. Shubham Kumar
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  2. Nidhi
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  3. Babita Thakur
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  4. Vagish Dwibedi
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  5. Jasdeep Singh
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Correspondence to Jasdeep Singh .

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Editors and Affiliations

  1. Department of Pharmaceutical Chemistry, DIT University, Dehradun, Uttarakhand, India

    Santosh Kumar Rath

  2. University Institute of Biotechnology, Chandigarh University, Punjab, Chandigarh, India

    Vagish Dwibedi

  3. Department of Biotechnology, Smt. S. S. Patel Nootan Science and Commerce College, Sankalchand Patel University, Visnagar, Gujarat, India

    Azamal Husen

  4. Department of Animal Biosciences, University of Guelph, Guelph, ON, Canada

    Nadeem Akhtar

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Kumar, S., Nidhi, Thakur, B., Dwibedi, V., Singh, J. (2024). Fundamentals of Drug Delivery. In: Rath, S.K., Dwibedi, V., Husen, A., Akhtar, N. (eds) Nanomaterials for Drug Delivery and Neurological Diseases Management. Smart Nanomaterials Technology. Springer, Singapore. https://doi.org/10.1007/978-981-97-0308-1_3

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