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Modulating tumour metabolism enhances gold nanoparticle radiosensitisation in HPV-negative head and neck cancer
BackgroundRadiotherapy is a major therapeutic modality for locally advanced head and neck cancer. However, the effectiveness of radiotherapy is...
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Oxygen tank for synergistic hypoxia relief to enhance mitochondria-targeted photodynamic therapy
BackgroundMitochondria play an essential role in cellular redox homeostasis maintenance and meanwhile serve as an important target for organelle...
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Arginine-peptide complex-based assemblies to combat tumor hypoxia for enhanced photodynamic therapeutic effect
Tumor hypoxia is one of the major factors restricting the photodynamic therapy (PDT) efficacy. To address this problem, we designed an...
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Structural Aspects of Organic Compounds as Proteasome Inhibitors Addressed to Several Diseases
The proteasome is a multi-subunit proteolytic complex structure that plays an important role in the cell cycle and has emerged as a key target...
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Synergetic lethal energy depletion initiated by cancer cell membrane camouflaged nano-inhibitor for cancer therapy
Mitochondrial bioenergy plays a vital role in the occurrence and development of cancer. Although strategies to impede mitochondrial energy supply...
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Phototherapy techniques for the management of musculoskeletal disorders: strategies and recent advances
Musculoskeletal disorders (MSDs), which include a range of pathologies affecting bones, cartilage, muscles, tendons, and ligaments, account for a...
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Computationally guided high-throughput design of self-assembling drug nanoparticles
Nanoformulations of therapeutic drugs are transforming our ability to effectively deliver and treat a myriad of conditions. Often, however, they are...
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Designing Novel Photocatalysts for Disinfection of Multidrug-Resistant Waterborne Bacteria
Water is the main source of sustaining life. It is an indispensable need for flora and fauna alike. However, water is often contaminated by...
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Wet Media Milling: An Effective Way to Solve Drug Solubility Issue
Drug synthesis, high-throughput screening generates billions of poorly soluble drugs which are neglected in further developments due to solubility...
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Wet Media Milling: An Effective Way to Solve Drug Solubility Issue
Drug synthesis, high-throughput screening generates billions of poorly soluble drugs which are neglected in further developments due to solubility...
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Nanotechnology-Based Drug Delivery Systems
In recent years, there has been a considerable interest in the development of novel drug delivery systems using nanotechnology. Nanoparticles...
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Pharmaceutical Applications of Nanoparticle Carriers
Once it has been administered, an active principle still has to face many physiological barriers on the way to its target, and this may significantly...