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The Effect of Benzyl Alcohol on the Voltage-Current Characteristics of Tethered Lipid Bilayers
In this study a lipid bilayer membrane model was used in which the bilayer is tethered to a solid substrate with molecular tethers. Voltage–current...
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Statistically unbiased prediction enables accurate denoising of voltage imaging data
Here we report SUPPORT (statistically unbiased prediction utilizing spatiotemporal information in imaging data), a self-supervised learning method...
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Rhodopsin Channel Activity Can Be Evaluated by Measuring the Photocurrent Voltage Dependence in Planar Bilayer Lipid Membranes
AbstractThe studies of the functional properties of retinal-containing proteins often include experiments in model membrane systems, e.g.,...
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Kinetic and thermodynamic modeling of a voltage-gated sodium channel
Like all biological and chemical reactions, ion channel kinetics are highly sensitive to changes in temperature. Therefore, it is prudent to...
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Biophysical reviews top five: voltage-dependent charge movement in nerve and muscle
The discovery of gating currents and asymmetric charge movement in the early 1970s represented a remarkable leap forward in our understanding of the...
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An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG
BackgroundCyclic Nucleotide-Binding Domain (CNBD)-family channels display distinct voltage-sensing properties despite sharing sequence and structural...
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Multiple mechanisms contribute to fluorometry signals from the voltage-gated proton channel
Voltage-clamp fluorometry (VCF) supplies information about the conformational changes of voltage-gated proteins. Changes in the fluorescence...
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Role of BDNF in Neuroplasticity Associated with Alcohol Dependence
AbstractChronic alcohol consumption is characterized by disturbances of neuroplasticity. Brain-derived neurotrophic factor (BDNF) is believed to be...
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Molecular Basis of JZTX-III Inhibiting the Fast Inactivation of Voltage-Gated Sodium Channel Nav1.5
Prior research has established that **gzhaotoxin-III (JZTX-III) can selectively target Nav1.5 channels. It achieves this by anchoring the DII-S4...
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Quantal Properties of Voltage-Dependent Ca2+ Release in Frog Skeletal Muscle Persist After Reduction of [Ca2+] in the Sarcoplasmic Reticulum
In skeletal muscle, the Ca 2+ release flux elicited by a voltage clamp pulse rises to an early peak that inactivates rapidly to a much lower steady...
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Examining Mechanisms for Voltage-Sensitive Calcium Channel-Mediated Secretion Events in Bone Cells
In addition to their well-described functions in cell excitability, voltage-sensitive calcium channels (VSCCs) serve a critical role in calcium (Ca 2+ )...
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Voltage-Gated Calcium Channel Auxiliary β Subunits
High-voltage-activated Ca2+ channels (HVACCs) convert information encoded in action potentials into Ca2+ fluxes that control critical biological...
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Pharmacology of Voltage-Gated Calcium Channels at Atomic Resolution
Voltage-gated calcium channels are evolutionarily related transmembrane signaling proteins that mediate calcium entry during action potentials and...
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Calmodulin Regulation of Voltage-Gated Calcium Channels
The ubiquitous Ca2+ sensor calmodulin (CaM) serves as a preeminent modulator of voltage-gated Ca2+ channels, exerting rapid and powerful feedback...
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Voltage-gated ion channels in central neurons of Helicoverpa armigera as potential targets for cycloxaprid: a cis-configuration neonicotinoid insecticide
Cycloxaprid is a novel cis -neonicotinoid, mainly acting on the nicotinic acetylcholine receptor; however, it is not clear whether cycloxaprid can act...
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Voltage-Dependent Calcium Channels (CaVs) and CatSper in Spermatogenic and Sperm Cells
As in most cell types, intracellular Ca2+ regulates many fundamental physiological functions in sperm and its progenitors. Ca2+ permeable and...
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Voltage-Gated Calcium Channels (VGCCs) and Synaptic Transmission
The intrinsic characteristics of neurons, as well as their distinctive firing properties, are defined by the intricate interplay of different ion...
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An electron counting algorithm improves imaging of proteins with low-acceleration-voltage cryo-electron microscope
Relative to the 300-kV accelerating field, electrons accelerated under lower voltages are potentially scattered more strongly. Lowering the...
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Subunit Architecture and Atomic Structure of Voltage-Gated Ca2+ Channels
Voltage-gated calcium channels mediate calcium entry into cells in response to membrane depolarization. The high-voltage-activated Ca2+ channels that...
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Novel Insights into the Role of Voltage-Gated Calcium Channel Genes in Psychiatric Disorders
Calcium entering via voltage-gated calcium channels is a second messenger key for cellular functions including gene expression, neuronal...