Search
Search Results
-
Interleukin-4 protects retinal ganglion cells and promotes axon regeneration
BackgroundThe preservation of retinal ganglion cells (RGCs) and the facilitation of axon regeneration are crucial considerations in the management of...
-
The molecular mechanism of human stem cell-derived extracellular vesicles in retinal repair and regeneration
Extracellular vesicles (EVs), including microvesicles (MVs) and exosomes, play a critical role in metabolic regulation and intracellular...
-
Molecular hydrogen promotes retinal vascular regeneration and attenuates neovascularization and neuroglial dysfunction in oxygen-induced retinopathy mice
BackgroundRetinopathy of Prematurity (ROP) is a proliferative retinal vascular disease occurring in the retina of premature infants and is the main...
-
Purified regenerating retinal neurons reveal regulatory role of DNA methylation-mediated Na+/K+-ATPase in murine axon regeneration
While embryonic mammalian central nervous system (CNS) axons readily grow and differentiate, only a minority of fully differentiated mature CNS...
-
Organ Regeneration Without Relying on Regeneration-Dedicated Stem Cells
The classic conception of tissue regeneration assumed the existence of tissue-proper regeneration stem cellsregeneration stem cells that are set...
-
Therapeutic Potential of Oral-Derived Mesenchymal Stem Cells in Retinal Repair
The retina has restricted regeneration ability to recover injured cell layer because of reduced production of neurotrophic factors and increased...
-
Molecular basis of retinal remodeling in a zebrafish model of retinitis pigmentosa
A hallmark of inherited retinal degenerative diseases such as retinitis pigmentosa (RP) is progressive structural and functional remodeling of the...
-
Nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina
Retinal Müller glia function as injury-induced stem-like cells in zebrafish but not mammals. However, insights gleaned from zebrafish have been...
-
Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration
Although age-related macular degeneration (AMD) is a multifactorial disorder with angiogenic, immune, and inflammatory components, the most common...
-
Towards Stem/Progenitor Cell-Based Therapies for Retinal Degeneration
Retinal degeneration (RD) is a leading cause of blindness worldwide and includes conditions such as retinitis pigmentosa (RP), age-related macular...
-
TRIM9 promotes Müller cell–derived retinal stem cells to differentiate into retinal ganglion cells by regulating Atoh7
Glaucoma is a multifactorial, irreversible blinding eye disease characterized by a large number of retinal ganglion cell (RGC) deaths. Müller...
-
Stem Cells Application in Eye Regeneration and Restoration of Vision
Eye tissues mostly comprise terminally differentiated cells or limited sets of stem cells with little potential for differentiation and regeneration....
-
Therapeutic effects of mesenchymal stem cells-derived extracellular vesicles’ miRNAs on retinal regeneration: a review
Extracellular vesicles (EVs), which consist of microvesicles and exosomes, are secreted from all cells to transform vital information in the form of...
-
Application of Human Stem Cell Derived Retinal Organoids in the Exploration of the Mechanisms of Early Retinal Development
The intricate neural circuit of retina extracts salient features of the natural world and forms bioelectric impulse as the origin of vision. The...
-
Cell-based Therapies for Corneal and Retinal Disorders
Maintenance of the visual function is the desired outcome of ophthalmologic therapies. The shortcomings of the current treatment options, like...
-
Regulation of chromatin organization during animal regeneration
Activation of regeneration upon tissue damages requires the activation of many developmental genes responsible for cell proliferation, migration,...
-
Blood-Retinal Barrier Development and Potential for Regeneration in Blinding Eye Disease
The blood-retinal barrier (BRB) creates the defined retinal environment necessary for neuronal signaling and vision. The well-developed tight...
-
Deficiency of copper responsive gene stmn4 induces retinal developmental defects
As part of the central nervous system (CNS), the retina senses light and also conducts and processes visual impulses. The damaged development of the...
-
Stem Cells Application in Eye Regeneration and Restoration of Vision
Eye tissues mostly comprise terminally differentiated cells or limited sets of stem cells with little potential for differentiation and regeneration....
-
Peripheral monocytes and neutrophils promote photoreceptor cell death in an experimental retinal detachment model
Photoreceptor cell death and immune cell infiltration are two major events that contribute to retinal degeneration. However, the relationship between...
