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Utilization of Freeze-Thawing Method for High-level Expression of Functional Human Epidermal Growth Factor (hEGF)
The wide applications of human epidermal growth factor (hEGF) as an efficient mitogen agent in the clinical, health, and cosmetic industries has made...
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Economic optimization of expression of soluble human epidermal growth factor in Escherichia coli
Human epidermal growth factor (hEGF) has multiple biological functions, such as promoting cell proliferation, differentiation, and migration. In...
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Enhancement of recombinant human keratinocyte growth factor 1 protein production in transgenic hazelnut (Corylus avellana L.) plant cell suspension cultures under RAmy3D inducible promoter
Recombinant human KGF1 (rhKGF) is a fibroblast growth factor that promotes epidermal cell proliferation, differentiation, migration, and wound...
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Design and construction of scFv-PE35KDEL as a novel immunotoxin against human epidermal growth factor receptor 2 for cancer therapy
ProposeHuman epidermal growth factor receptor 2 (HER2) is overexpressed on the surface of some kinds of cancer cells including breast cancer. In this...
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Rapid Screening for High Expressing Multicopy Recombinants and Enhanced Epidermal Growth Factor (EGF) Protein Production Using Pichia Pastoris
Epidermal growth factor (EGF) is a highly effective stimulator which promotes cell proliferation and this has led it to being proposed as a...
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Milk fat-globule epidermal growth factor 8: A potential Regulator of Cutaneous Wound Healing
Destroying the integrity of the skin may causes disability and even death from injury or illness. Wound healing is a core mechanism to maintain skin...
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Generation of Properly Folded Epidermal Growth Factor-Like (EGF) Repeats and Glycosyltransferases Enables In Vitro O-Glycosylation
The epidermal growth factor-like (EGF) domain is an evolutionarily conserved motif found widely distributed among numerous secreted and...
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Epidermal Growth Factor Mediates Up-Regulation of URGCP Oncogene in Human Hepatoma Cancer Cells
AbstractHepatocellular Carcinoma (HCC) is the fourth leading cause of cancer-related death in the World. Epidermal Growth Factor Receptor (EGFR)...
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Recombinant Expression of Complex Proteins in Human Cell Lines
Coagulation factors, as factor VII, VIII, and IX, are complex proteins which are very difficult to express. Blood coagulation factor IX is a vitamin...
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Recombinant SLURP-1 Inhibits Growth and Migration of U251 MG Glioma by Cell Cycle Arrest and Modulation of MAPK and AKT Signaling Pathways
AbstractA recombinant analog of the human SLURP-1 protein, rSLURP-1, effectively inhibits the growth of carcinomas by interaction with the α7-type...
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A novel recombinant ORF7-siRNA delivered by flexible nano-liposomes inhibits varicella zoster virus infection
BackgroundVaricella zoster virus (VZV), which is a human restricted alpha-herpesvirus, causes varicella (chickenpox) and zoster (shingles). The...
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IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells
Triple-negative breast cancer (TNBC) has a poor prognosis compared to other breast cancer subtypes. Although epidermal growth factor receptor (EGFR)...
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Non-alcoholic fatty liver disease promotes breast cancer progression through upregulated hepatic fibroblast growth factor 21
Non-alcoholic fatty liver disease (NAFLD) has been shown to influence breast cancer progression, but the underlying mechanisms remain unclear. In...
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Effect of prepropeptide replacement on γ-carboxylation and activity of recombinant coagulation factor IX
Based on observations indicating that the γ-carboxylase enzyme has a lower affinity for the protein C (PC) propeptide and that the γ-carboxylase...
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Myc-dependent dedifferentiation of Gata6+ epidermal cells resembles reversal of terminal differentiation
Dedifferentiation is the process by which terminally differentiated cells acquire the properties of stem cells. During mouse skin wound healing, the...
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New Recombinant Carriers Binding Specifically to the Epidermal Growth Factor Receptor
AbstractNew recombinant carriers—modular nanotransporters (MNTs)—with N-terminal ligand module to the epidermal growth factor receptor (EGFR) were...
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Progress in fed-batch culture for recombinant protein production in CHO cells
AbstractNearly 80% of the approved human therapeutic antibodies are produced by Chinese Hamster Ovary (CHO) cells. To achieve better cell growth and...
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Biology and therapeutic targeting of vascular endothelial growth factor A
The formation of new blood vessels, called angiogenesis, is an essential pathophysiological process in which several families of regulators have been...
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Translocation from the chloroplast stroma into the thylakoid lumen allows expression of recombinant epidermal growth factor in transplastomic tobacco plants
Chloroplast transformation has many potential advantages for the production of recombinant proteins in plants. However, it has been reported that...
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Human Blood Serum Counteracts EGFR/HER2-Targeted Drug Lapatinib Impact on Squamous Carcinoma SK-BR-3 Cell Growth and Gene Expression
AbstractLapatinib is a targeted therapeutic inhibiting HER2 and EGFR proteins. It is used for the therapy of HER2-positive breast cancer, although...
