Search
Search Results
-
CRISPR-based gene expression platform for precise regulation of bladder cancer
The development of compact CRISPR systems has facilitated delivery but has concurrently reduced gene editing efficiency, thereby limiting the further...
-
Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos
Metabolism feeds into the regulation of epigenetics via metabolic enzymes and metabolites. However, metabolic features, and their impact on...
-
Precise and scalable self-organization in mammalian pseudo-embryos
Gene expression is inherently noisy, posing a challenge to understanding how precise and reproducible patterns of gene expression emerge in mammals....
-
Nonspecific Interactions in Transcription Regulation and Organization of Transcriptional Condensates
AbstractEukaryotic cells are characterized by a high degree of compartmentalization of their internal contents, which ensures precise and controlled...
-
The Significance of Repressive Processes in Developmental Regulation
Encountering a developmental process confined to a limited time window or a restricted embryonic area, one may deem that the mechanism to activate...
-
Neurogenic Regulation of Cerebral Blood Flow
AbstractThe brain has a well-developed vascular network that allows it to consume up to 15% of cardiac output at its low weight relative to the...
-
Regulation of chromatin organization during animal regeneration
Activation of regeneration upon tissue damages requires the activation of many developmental genes responsible for cell proliferation, migration,...
-
Activation-inducible CAR expression enables precise control over engineered CAR T cell function
CAR T cell therapy is a rapidly growing area of oncological treatments having a potential of becoming standard care for multiple indications....
-
In silico analysis and designing gRNA constructs for the precise modification of the OsTMS5 gene in rice (Oryza sativa L.): a comprehensive study and construct development for crop improvement
The CRISPR/Cas9 system represents a state-of-the-art technology for precise genome editing in plants. In this study, we performed in silico and...
-
Epigenetic Regulation of Genome Function in Populus
Change is a constant in life, and being able to respond to change is essential for every living being. This may be especially true for sessile...
-
Noncoding RNA Regulation in Plant Responses to Abiotic Stress
This chapter aims to provide an understanding of the regulatory and functional roles of noncoding RNAs (ncRNAs) in plant stress responses. This study...
-
Self-Regulation in Competitive Sports
The chapter provides an overview of self-regulation in competitive sports. Self-regulation refers to conscious as well as unconscious processes that...
-
A guide to precise measurements of isotope abundance by ESI-Orbitrap MS
Stable isotopes of carbon, hydrogen, nitrogen, oxygen and sulfur are widespread in nature. Nevertheless, their relative abundance is not the same...
-
Splicing regulation through biomolecular condensates and membraneless organelles
Biomolecular condensates, sometimes also known as membraneless organelles (MLOs), can form through weak multivalent intermolecular interactions of...
-
The molecular basis of translation initiation and its regulation in eukaryotes
The regulation of gene expression is fundamental for life. Whereas the role of transcriptional regulation of gene expression has been studied for...
-
Opportunities and challenges with CRISPR-Cas mediated homologous recombination based precise editing in plants and animals
Key messageWe summarise recent advancements to achieve higher homologous recombination based gene targeting efficiency in different animals and...
-
Regulation of Human DNA Primase-Polymerase PrimPol
AbstractTransmission of genetic information depends on successful completion of DNA replication. Genomic DNA is subjected to damage on a daily basis....
-
Dietary macronutrient composition impacts gene regulation in adipose tissue
Diet is a key lifestyle component that influences metabolic health through several factors, including total energy intake and macronutrient...
-
Synthetic Biology Approaches to Posttranslational Regulation in Plants
AbstractTo date synthetic biology approaches involving creation of functional genetic modules are used in a wide range of organisms. In plants, such...
-
Epigenetic and Posttranslational Regulation of Ferroptosis
Ferroptosis is tightly controlled by pro-ferroptotic pathways, which involve iron and lipid metabolism, as well as anti-ferroptotic pathways, such as...