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Targeting tumor innervation: premises, promises, and challenges
A high intratumoral nerve density is correlated with poor survival, high metastasis, and high recurrence across multiple solid tumor types. Recent...
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Morphological Peculiarities of Innervation of Rat Epicardial Adipose Tissue in Early Postnatal Ontogenesis
AbstractThe study aimed to analyze the structure and innervation of the epicardial adipose tissue (EAT) in the aortic-pulmonary region of the rat...
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Intrinsic innervation of the ovary and its variations in the rat senescence process
Ovarian functions decrease with perimenopause. The ovary has extrinsic innervation, but the neural influence on ovarian functions and dysfunction is...
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Neurogenic Regulation of Cerebral Blood Flow
AbstractThe brain has a well-developed vascular network that allows it to consume up to 15% of cardiac output at its low weight relative to the...
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Embryonic Spinal Cord Innervation in Human Trunk Organogenesis Gastruloids: Cardiac Versus Enteric Customization and Beyond
Trunk-biased human gastruloids provide the ability to couple developmentally relevant spinal neurogenesis and organ morphogenesis via spatiotemporal...
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General Morphology of the Mammalian Carotid Body
The carotid body (CB) is the main peripheral arterial chemoreceptor that registers the levels of pO2, pCO2 and pH in the blood and responds to their...
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Slowing down as we age: aging of the cardiac pacemaker’s neural control
The cardiac pacemaker ignites and coordinates the contraction of the whole heart, uninterruptedly, throughout our entire life. Pacemaker rate is...
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Comparative Analysis of Disorders of Heart Rhythm Regulation Mechanisms Induced in Newborn Rats by Nickel Chloride and the Acetylcholinesterase Inhibitor Physostigmine (Eserine)
AbstractA comparative analysis of heart rate variability (HRV) indices after injection of the acetylcholinesterase inhibitor (AChE)...
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The metabolic and functional roles of sensory nerves in adipose tissues
Homeostatic regulation of adipose tissue is critical for the maintenance of energy balance and whole-body metabolism. The peripheral nervous system...
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The role of age-associated autonomic dysfunction in inflammation and endothelial dysfunction
Aging of the cardiovascular regulatory function manifests as an imbalance between the sympathetic and parasympathetic (vagal) components of the...
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Neural Regulation of Cardiac Rhythm
The autonomic nervous system (ANS) regulates cardiac function, including chronotropy, inotropy, lusitropy, and dromotropy. The cardiac nervous system...
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Interactions between central nervous system and peripheral metabolic organs
According to Descartes, minds and bodies are distinct kinds of “substance”, and they cannot have causal interactions. However, in neuroscience, the...
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Differences in the regulatory mechanism of blood flow in the orofacial area mediated by neural and humoral systems
Marked blood flow (BF) changes mediated by the autonomic neural and humoral systems may be important for orofacial hemodynamics and functions....
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Clinical and Physiological Features of the Sympathetic Innervation of Arms and Hands
AbstractAnatomical and physiological features of sympathetic innervation provide a basis for develo** methods to treat sympathetic dysfunction....
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Systemic and local regulation of hematopoietic homeostasis in health and disease
Hematopoietic stem cells (HSCs) generate all blood cell lineages responsible for tissue oxygenation, life-long hematopoietic homeostasis and immune...
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PI3K signalling at the intersection of cardio-oncology networks: cardiac safety in the era of AI
Class I phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases. They are super elevated in many human cancer types and exert their main...
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Platinized graphene fiber electrodes uncover direct spleen-vagus communication
Neural interfacing nerve fascicles along the splenic neurovascular plexus (SNVP) is needed to better understand the spleen physiology, and for...
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Optogenetic Control of Heart Rhythm: Lightly Guiding the Cardiac Pace
It is well appreciated that, differently from skeletal muscles, the heart contracts independently from neurogenic inputs. However, the speed and...
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Medetomidine/midazolam/fentanyl narcosis alters cardiac autonomic tone leading to conduction disorders and arrhythmias in mice
Arrhythmias are critical contributors to cardiovascular morbidity and mortality. Therapies are mainly symptomatic and often insufficient, emphasizing...
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The Role of Neuro-Cardiac Junctions in Sympathetic Regulation of the Heart
AbstractOne of the important mechanisms of cardiac regulation is realized via sympathetic innervation of cardiac myocytes. Axons of the...
