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Nucleic Acids
Nucleic acids consist of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) which was first discovered by Friedrich Miescher in 1869. DNA are the...
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Isolation of Nucleic Acids
Nucleic acid isolation is the process of extracting DNA or RNA from cells in a relatively pure form that can be used for downstream investigations,...
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Evaluating Cationic Nanoparticles as Carriers of Antiviral Nucleic Acids
Nanoparticle carriers enable the multivalent delivery of nucleic acids to cells and protect them from degradation. In this chapter, we present a...
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Therapeutic Nucleic Acids Against Herpes Simplex Viruses (A Review)
AbstractThe Herpes simplex virus (HSV) causes a wide range of diseases ranging from relatively mild primary skin lesions to severe and often fatal...
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Cell-Penetrating Peptides as Vehicles for Delivery of Therapeutic Nucleic Acids. Mechanisms and Application in Medicine
AbstractCurrently, nucleic acid therapeutics are actively developed for the treatment and prophylactic of metabolic disorders and oncological,...
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Replicative senescence and high glucose induce the accrual of self-derived cytosolic nucleic acids in human endothelial cells
Recent literature shows that loss of replicative ability and acquisition of a proinflammatory secretory phenotype in senescent cells is coupled with...
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Twist-stretch relations in nucleic acids
Nucleic acids are highly deformable helical molecules constantly stretched, twisted and bent in their biological functioning. Single molecule...
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ATP and nucleic acids competitively modulate LLPS of the SARS-CoV2 nucleocapsid protein
SARS-CoV-2 nucleocapsid (N) protein with very low mutation rates is the only structural protein which not only functions to package viral genomic...
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Latest Trends in Nucleic Acids’ Engineering Techniques Applied to Precision Medicine
Nucleic acids are paving the way for advanced therapeutics. Unveiling the genome enabled a better understanding of unique genotype–phenotype...
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Arg/Lys-containing IDRs are cryptic binding domains for ATP and nucleic acids that interplay to modulate LLPS
Most membrane-less organelles (MLOs) formed by LLPS contain both nucleic acids and IDR-rich proteins. Currently while IDRs are well-recognized to...
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Fluorochromes That Bind Nucleic Acids
Chapter 16 is dedicated to fluorochromes used in nucleic acid analysis. The chapter classifies this group of...
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Basic Idea About Nucleic Acids for Nonexperts
Nucleic acids form the basis of all life on earth. The two types of nucleic acids are DNA and RNA. DNA primarily stores genetic information, whereas...
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Biological Defense I: Protection from Foreign Nucleic Acids
All organisms have to protect themselves from the invasion of other harmful species. There are very different systems of defense in various...
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Sensors of Intracellular Nucleic Acids Activating STING-Dependent Production of Interferons in Immunocompetent Cells
AbstractCurrently, foreign DNA or RNA sensor proteins, which play an important role in innate immunity, are of great interest as a new avenue for...
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CryoREAD: de novo structure modeling for nucleic acids in cryo-EM maps using deep learning
DNA and RNA play fundamental roles in various cellular processes, where their three-dimensional structures provide information critical to...
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Protein transfection via spherical nucleic acids
The efficient transfection of functional proteins into cells can serve as a means for regulating cellular processes toward solving fundamental...
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(Dys)functional insights into nucleic acids and RNA-binding proteins modulation of the prion protein and α-synuclein phase separation
Prion diseases are prototype of infectious diseases transmitted by a protein, the prion protein (PrP), and are still not understandable at the...
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The End Restraint Method for Mechanically Perturbing Nucleic Acids In Silico
Far from being a passive information store, the genome is a mechanically dynamic and diverse system in which torsion and tension fluctuate and...
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Organic Extraction of Nucleic Acids Using Ethanol Precipitation or Microcon® Centrifugal Filter Purification Methods
The use of organic solvents to separate nucleic acids from other cell components is a common practice among many scientific fields, including...