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Neurotrophin growth factors and their receptors as promising blood biomarkers for Alzheimer’s Disease: a gene expression analysis study
BackgroundAlzheimer’s disease (AD) is a multifaceted neurological ailment affecting more than 50 million individuals globally, distinguished by a...
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Redundancy of p75NTR neurotrophin receptor function in development, growth and fertility in the rat
The p75NTR neurotrophin receptor has positive and negative roles regulating cell survival in the nervous system. Unambiguous interpretation of p75NTR...
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Serum Levels of Growth-Associated Protein-43 and Neurotrophin-3 in Childhood Epilepsy and Their Relation to Zinc Levels
BackgroundEpilepsy is one of the most common neurological disorders, and it places a significant economic strain on the healthcare system around the...
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Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons
Deficits in axonal transport are one of the earliest pathological outcomes in several models of amyotrophic lateral sclerosis (ALS), including SOD1 G93A...
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The role of the PI3K/AKT signalling pathway in the corneal epithelium: recent updates
Phosphatidylinositol 3 kinase (PI3K)/AKT (also called protein kinase B, PKB) signalling regulates various cellular processes, such as apoptosis, cell...
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Converged avenues: depression and Alzheimer’s disease– shared pathophysiology and novel therapeutics
Depression, a highly prevalent disorder affecting over 280 million people worldwide, is comorbid with many neurological disorders, particularly...
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Exploration of interaction interface of TRKβ/BDNF through fingerprint analysis to disinter potential agonists
Tyrosine Kinase beta (TRKβ), is a type I membrane receptor which plays a major role in various signalling pathways. TRKβ was found to be upregulated...
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Natural compound targeting BDNF V66M variant: insights from in silico docking and molecular analysis
Brain-Derived Neurotrophic Factor ( BDNF ) is a neurotrophin gene family gene that encodes proteins vital for the growth, maintenance, and survival of...
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Insights and opportunities at the crossroads of cancer and neuroscience
The biological and pathological importance of mutual interactions between the nervous system and cancer have become increasingly evident. The...
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Sleep-associated insulin resistance promotes neurodegeneration
Lifestyle modification can lead to numerous health issues closely associated with sleep. Sleep deprivation and disturbances significantly affect...
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γ-Enolase enhances Trk endosomal trafficking and promotes neurite outgrowth in differentiated SH-SY5Y cells
BackgroundNeurotrophins can activate multiple signalling pathways in neuronal cells through binding to their cognate receptors, leading to...
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Selective motor activation in organelle transport along axons
The active transport of organelles and other cargos along the axon is required to maintain neuronal health and function, but we are just beginning to...
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Running and swimming prevent the deregulation of the BDNF/TrkB neurotrophic signalling at the neuromuscular junction in mice with amyotrophic lateral sclerosis
Nerve-induced muscle contraction regulates the BDNF/TrkB neurotrophic signalling to retrogradely modulate neurotransmission and protect the...
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The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders
Sonic hedgehog (Shh) signaling is an essential central nervous system (CNS) pathway involved during embryonic development and later life stages....
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Local and systemic mechanisms that control the hair follicle stem cell niche
Hair follicles are essential appendages of the mammalian skin, as hair performs vital functions of protection, thermoregulation and sensation. Hair...
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Differentiation of Mesenchymal Stem Cells to Neuroglia: in the Context of Cell Signalling
The promise of engineering specific cell types from stem cells and rebuilding damaged or diseased tissues has fascinated stem cell researchers and...
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Vasorin contributes to lung injury via FABP4-mediated inflammation
BackgroundLung injury caused by pulmonary inflammation is one of the main manifestations of respiratory diseases. Vasorin (VASN) is a cell-surface...
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Transcriptomic Variation of Amphiprion Percula (Lacepède, 1802) in Response to Infection with Cryptocaryon Irritans Brown, 1951
Cryptocaryon irritans (Brown
1951 ) frequently infect the Pomacentridae fishes causing severe economic losses. However, the anti- C . irritans ’...
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The extensive transgenerational transcriptomic effects of ocean acidification on the olfactory epithelium of a marine fish are associated with a better viral resistance
BackgroundProgressive CO 2 -induced ocean acidification (OA) impacts marine life in ways that are difficult to predict but are likely to become...
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NPC transplantation rescues sci-driven cAMP/EPAC2 alterations, leading to neuroprotection and microglial modulation
Neural progenitor cell (NPC) transplantation represents a promising treatment strategy for spinal cord injury (SCI); however, the underlying...
