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Chaperone proteins and peroxisomal protein import
Peroxisomes are ubiquitous organelles present in most eukaryotic cells. Their role in cellular metabolism is diverse among species. An array of genes...
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Molecular Chaperone Receptors: An Update
Extracellular heat shock proteins (HSP) play important roles in cell signaling and immunity. Many of these effects are mediated by surface receptors...
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Cdc37 as a Co-chaperone to Hsp90
The co-chaperone p50/Cdc37 is an important partner for Hsp90, assisting in molecular chaperone activities, particularly with regard to the regulation...
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HSP70-HSP90 Chaperone Networking in Protein-Misfolding Disease
Molecular chaperones and their associated co-chaperones are essential in health and disease as they are key facilitators of protein-folding, quality...
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Maturation and Assembly of mTOR Complexes by the HSP90-R2TP-TTT Chaperone System: Molecular Insights and Mechanisms
The mechanistic target of rapamycin (mTOR) is a master regulator of cell growth and metabolism, integrating environmental signals to regulate...
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The chaperone system in cancer therapies: Hsp90
The chaperone system (CS) of an organism is composed of molecular chaperones, chaperone co-factors, co-chaperones, and chaperone receptors and...
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CHIP: A Co-chaperone for Degradation by the Proteasome and Lysosome
Protein homeostasis relies on a balance between protein folding and protein degradation. Molecular chaperones like Hsp70 and Hsp90 fulfill...
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Visualizing chaperone-mediated multistep assembly of the human 20S proteasome
Dedicated assembly factors orchestrate the stepwise production of many molecular machines, including the 28-subunit proteasome core particle (CP)...
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Proteomic Profiling of the Extracellular Vesicle Chaperone in Cancer
Molecular chaperones are widely distributed intracellular proteins that play essential roles in maintaining proteome function by assisting in the...
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Complementation Assays for Co-chaperone Function
The development of mutant microorganisms lacking J domain proteins (JDPs; formerly called Hsp40s) has enabled the development of complementation...
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Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation
ATP-independent molecular chaperones are important for maintaining cellular fitness but the molecular determinants for preventing aggregation of...
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New ruthenium-xanthoxylin complex eliminates colorectal cancer stem cells by targeting the heat shock protein 90 chaperone
In this work, we describe a novel ruthenium-xanthoxylin complex, [Ru(phen) 2 (xant)](PF 6 ) (RXC), that can eliminate colorectal cancer (CRC) stem cells...
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Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space
Mitochondria, double-membrane organelles, are known to participate in a variety of metabolic and signal transduction pathways. The intermembrane...
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Enhanced drought and salt tolerance of Arabidopsis thaliana by ectopic expression of the molecular chaperone artemin from Artemia urmiana
Due to the resistance of Artemia urmiana to salt stress, researchers have isolated and investigated Artemin, the most prevalent protein within the...
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Control of meiotic crossover interference by a proteolytic chaperone network
Meiosis is a specialized eukaryotic division that produces genetically diverse gametes for sexual reproduction. During meiosis, homologous...
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Resolving chaperone-assisted protein folding on the ribosome at the peptide level
Protein folding in vivo begins during synthesis on the ribosome and is modulated by molecular chaperones that engage the nascent polypeptide. How...
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The histone chaperone function of Daxx is dispensable for embryonic development
Daxx functions as a histone chaperone for the histone H3 variant, H3.3, and is essential for embryonic development. Daxx interacts with Atrx to form...
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Adaptive preservation of orphan ribosomal proteins in chaperone-dispersed condensates
Ribosome biogenesis is among the most resource-intensive cellular processes, with ribosomal proteins accounting for up to half of all newly...
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A chaperone-like function of FUS ensures TAZ condensate dynamics and transcriptional activation
The Hippo pathway has important roles in organ development, tissue homeostasis and tumour growth. Its downstream effector TAZ is a transcriptional...
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Chaperone-mediated autophagy in neurodegenerative diseases: mechanisms and therapy
Chaperone-mediated autophagy (CMA) is the selective degradation process of intracellular components by lysosomes, which is required for the...
