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Bioinformatics Analysis of miRNA Sequencing Data
The bioinformatics analysis of miRNA is a complicated task with multiple operations and steps involved from processing of raw sequence data to...
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miRNA Biogenesis and Regulation of Diseases: An Updated Overview
MicroRNAs (miRNAs) are small RNA molecules, with their role in gene silencing and translational repression by binding to the target mRNAs. Since it...
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Endogenous miRNA Sponges
MicroRNAs (miRNAs) are a class of noncoding RNAs of 17–22 nucleotides in length with a critical function in posttranscriptional gene regulation....
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miRNA-7145-cuedc2 axis controls hematopoiesis through JAK1/STAT3 signaling pathway
Hematopoiesis ensures tissue oxygenation, and remodeling as well as immune protection in vertebrates. During embryogenesis, hemangioblasts are the...
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Nuclear receptor RXRα binds the precursor of miR-103 to inhibit its maturation
BackgroundThe maturation of microRNAs (miRNAs) successively undergoes Drosha, Dicer, and Argonaute ˗mediated processing, however, the intricate...
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Variant Analysis of miRNA Regulatory Genes in 35 Sporadic Lung Carcinoma Tumors
AbstractLung cancer is one of the cancer types with the highest mortality worldwide. The most frequently mutated genes known to be clinically...
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The emerging roles of miRNA-mediated autophagy in ovarian cancer
Ovarian cancer is one of the common tumors of the female reproductive organs. It has a high mortality rate, is highly heterogeneous, and early...
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Identification of Functionally Significant Polymorphic Variants in miRNA Genes in Carotid Atherosclerosis
miRNAs are vital molecules of gene expression. They are involved in the pathogenesis of various common diseases, including atherosclerosis, its risk...
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miRNA as biomarker in lung cancer
Lung cancer has a high prevalence and mortality due to its late diagnosis and limited treatment, so it is essential to find biomarkers that allow a...
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MiRNA-93: a novel signature in human disorders and drug resistance
miRNA-93 is a member of the miR-106b-25 family and is encoded by a gene on chromosome 7q22.1. They play a role in the etiology of various diseases,...
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An Integrated Bioinformatics and Functional Approach for miRNA Validation
MicroRNAs (miRNAs) are small (20–24 nucleotides) non-coding ribo-regulatory molecules with significant roles in regulating target mRNA and long...
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PRP4KA phosphorylates SERRATE and promotes its degradation to coordinate miRNA production
The precise regulation of miRNA is crucial for plant growth and fitness, which requires the presence of a core microprocessor composed of DICER-LIKE...
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The accumulation of modular serine protease mediated by a novel circRNA sponging miRNA increases Aedes aegypti immunity to fungus
BackgroundMosquitoes transmit many infectious diseases that affect human health. The fungus Beauveria bassiana is a biological pesticide that is...
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Cellular signaling modulated by miRNA-3652 in ovarian cancer: unveiling mechanistic pathways for future therapeutic strategies
MicroRNAs (miRNAs) are small non-coding RNA molecules that play pivotal roles in regulating gene expression and have been implicated in the...
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miRNA mediated regulation of nitrogen response and nitrogen use efficiency of plants: the case of wheat
Nitrogen (N) is needed for plant growth and development and is the major limiting nutrient due to its higher demand in agricultural production...
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Mouse microglia express unique miRNA-mRNA networks to facilitate age-specific functions in the develo** central nervous system
Microglia regulate multiple processes in the central nervous system, exhibiting a considerable level of cellular plasticity which is facilitated by...
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Integration of miRNA dynamics and drought tolerant QTLs in rice reveals the role of miR2919 in drought stress response
To combat drought stress in rice, a major threat to global food security, three major quantitative trait loci for ‘yield under drought stress’...
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The role of miRNA and lncRNA in heterotopic ossification pathogenesis
Heterotopic ossification (HO) is the formation of bone in non-osseous tissues, such as skeletal muscles. The HO could have a genetic or a non-genetic...
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miRNA- and RNAi-Mediated Metabolic Engineering in Plants
MicroRNAs (miRNAs) are endogenous, highly conserved, small regulatory RNA molecules with a size of 19–24 nucleotides, micro in structure and macro in...
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Understanding the evolution of miRNA biogenesis machinery in plants with special focus on rice
miRNA biogenesis process is an intricate and complex event consisting of many proteins working in a highly coordinated fashion. Most of these...
