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The Mediator complex regulates enhancer-promoter interactions
Enhancer-mediated gene activation generally requires physical proximity between enhancers and their target gene promoters. However, the molecular...
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The Transcriptional MEDIATOR Complex: Linking Root Development, Hormonal Responses, and Nutrient Stress
The MEDIATOR complex is a large multiprotein assembly ubiquitous to eukaryotic organisms that acts as a transcriptional coactivator. Although its...
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The Mediator complex as a master regulator of transcription by RNA polymerase II
The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits, controls many aspects of RNA polymerase II (Pol II) function....
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RhMED15a-like, a subunit of the Mediator complex, is involved in the drought stress response in Rosa hybrida
BackgroundRose ( Rosa hybrida ) is a globally recognized ornamental plant whose growth and distribution are strongly limited by drought stress. The...
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Regulation of fungal raw-starch-degrading enzyme production depends on transcription factor phosphorylation and recruitment of the Mediator complex
Filamentous fungus can produce raw-starch-degrading enzyme (RSDE) that efficiently degrades raw starch below starch gelatinization temperature....
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Formation of nuclear condensates by the Mediator complex subunit Med15 in mammalian cells
BackgroundThe Mediator complex is an evolutionarily conserved multi-subunit protein complex that plays major roles in transcriptional activation and...
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Comparative phylogenetic analysis of the mediator complex subunit in asparagus bean (Vigna unguiculata ssp. sesquipedialis) and its expression profile under cold stress
BackgroundThe mediator complex subunits (MED) constitutes a multiprotein complex, with each subunit intricately involved in crucial aspects of plant...
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Distinct roles for CKM–Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction
Precise control of gene expression underpins normal development. This relies on mechanisms that enable communication between gene promoters and other...
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Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics
Postnatal cell fate is postulated to be primarily determined by the local tissue microenvironment. Here, we find that Mediator 1 ( Med1 ) dependent...
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The Mediator Subunit OsMED16 Interacts with the WRKY Transcription Factor OsWRKY45 to Enhance Rice Resistance Against Magnaporthe oryzae
Rice blast, caused by Magnaporthe oryzae ( M. oryzae ), is one of the most common and damaging diseases of rice that limits rice yield and quality. The...
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Electro-oxidation of synthetic lignin with different mediators for the laccase mediator system (3-hydroxyanthranilic acid, 4-hydroxybenzoic acid, phenol red)
Three mediators for the laccase mediator system, 3-hydroxyanthranilic acid (3-HAA), 4-hydroxybenzoic acid (HBA), and phenol red (PR) were...
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MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
BackgroundThe mitochondrial gene MCCC2, a subunit of the heterodimer of 3-methylcrotonyl-CoA carboxylase, plays a pivotal role in catabolism of...
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An in vitro CRISPR screen of cell-free DNA identifies apoptosis as the primary mediator of cell-free DNA release
Clinical circulating cell-free DNA (cfDNA) testing is now routine, however test accuracy remains limited. By understanding the life-cycle of cfDNA,...
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Sprouty1 is a broad mediator of cellular senescence
Genes of the Sprouty family (Spry1-4) restrain signaling by certain receptor tyrosine kinases. Consequently, these genes participate in several...
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The transcription regulator ATF4 is a mediator of skeletal muscle aging
Aging slowly erodes skeletal muscle strength and mass, eventually leading to profound functional deficits and muscle atrophy. The molecular...
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Plasticizer phthalate esters degradation with a laccase from Trametes versicolor: effects of TEMPO used as a mediator and estrogenic activity removal
Phthalate esters (PAEs) are toxic and persistent chemicals that are ubiquitous in the environment and have attracted worldwide attention due to their...
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A Mutation in Mediator Subunit MED16A Suppresses Nodulation and Increases Arbuscule Density in Medicago truncatula
Nodulation in legumes is regulated to maintain carbon–nitrogen homeostasis. A systemic negative feedback pathway, Autoregulation of Nodulation (AON)...
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Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity
Obesity is a major risk factor for Coronavirus disease (COVID-19) severity; however, the mechanisms underlying this relationship are not fully...
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Is blood-brain barrier a probable mediator of non-invasive brain stimulation effects on Alzheimer’s disease?
Alzheimer’s disease (AD) is a complex neurodegenerative disease with no existing treatment leading to full recovery. The blood-brain barrier (BBB)...
