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Local Mechano-Dependent Calcium Influx Controls the Activity of Calcium-Dependent Potassium Channels of Big and Small Conductance in Human Lymphoma Cells
AbstractBurkitt’s lymphoma is an aggressive and fast-growing form of non-Hodgkin’s lymphoma with the highest invasive potential of all types of...
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Examining Mechanisms for Voltage-Sensitive Calcium Channel-Mediated Secretion Events in Bone Cells
In addition to their well-described functions in cell excitability, voltage-sensitive calcium channels (VSCCs) serve a critical role in calcium (Ca 2+ )...
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Cytosolic Calcium Distribution and Thrombin Receptor Activation
Since, receptor plays significant role in calcium signalling and to understand the mechanism of signalling in detail; an essential component is the...
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Calcium and Phosphate Ion Uptake, Distribution, and Homeostasis in Cells of Vertebrate Mineralized Tissues
The chapter considers mechanisms by which cells regulate calcium and phosphate ion homeostasis with respect to the induction of extracellular...
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How filopodia respond to calcium in the absence of a calcium-binding structural protein: non-channel functions of TRP
BackgroundFor many cell types, directional locomotion depends on their maintaining filopodia at the leading edge. Filopodia lack any Ca 2+ -binding...
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Orai, RyR, and IP3R channels cooperatively regulate calcium signaling in brain mid-capillary pericytes
Pericytes are multifunctional cells of the vasculature that are vital to brain homeostasis, yet many of their fundamental physiological properties,...
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Disruption of Calcium Homeostasis and Following Changes in Calcium Signaling in Neurons and Glial Cells in Response to Photodynamic Treatment
AbstractPhotodynamic impact on neurons and glial cells, causing oxidative stress and ischemic damage, is accompanied by disruption of calcium...
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On the role of calcium diffusion and its rapid buffering in intraflagellar signaling
We have considered the realistic mechanism of rapid Ca 2+ (calcium ion) buffering within the wave of calcium ions progressing along the flagellar...
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Voltage-Gated Calcium Channels (VGCCs) and Synaptic Transmission
The intrinsic characteristics of neurons, as well as their distinctive firing properties, are defined by the intricate interplay of different ion...
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PYK2 senses calcium through a disordered dimerization and calmodulin-binding element
Multidomain kinases use many ways to integrate and process diverse stimuli. Here, we investigated the mechanism by which the protein tyrosine kinase...
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Calcium imaging: a technique to monitor calcium dynamics in biological systems
Calcium ion (Ca 2+ ) is a multifaceted signaling molecule that acts as an important second messenger. During the course of evolution, plants and...
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Computational modeling of AMPK and mTOR crosstalk in glutamatergic synapse calcium signaling
Neuronal energy consumption is vital for information processing and memory formation in synapses. The brain consists of just 2% of the human body’s...
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Calcium Homeostasis in Spermatozoa: Regulatory Mechanisms and Biological Significance
Abstract —Calcium is one of the most important elements for intracellular signaling. Its role is so big and complex that we can distinguish various...
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Measurements of Calcium in Chromaffin Cell Organelles Using Targeted Aequorins
The molecular mechanisms that mediate and regulate calcium (Ca2+) fluxes through the membranes of intracellular organelles play a key role in the...
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Cav1 L-Type Calcium Channels in the Auditory and Visual Systems
In sensory neurons, presynaptic voltage-gated L-type calcium channels (Cav1) mediate calcium influx as a first important step in synaptic...
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Heat stress-induced NO enhanced perylenequinone biosynthesis of Shiraia sp. via calcium signaling pathway
AbstractPerylenequinones (PQs) are natural photosensitizing compounds used as photodynamic therapy, and heat stress (HS) is the main limiting factor...
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Voltage-Gated Calcium Channels in Invertebrates
The α1, β, and α2δ subunits of voltage-gated calcium channels emerged before animals, and are present in all animal genomes, including those that...
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Serum Calcium and Magnesium Levels in Women with Uterine Fibroids in Southwest Nigeria: a Cross-sectional Study
Studies have suggested the potential roles of serum macronutrients such as calcium and magnesium in the development of uterine fibroids. The primary...
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Mitochondrial calcium uniporter channel gatekee** in cardiovascular disease
The mitochondrial calcium ( m Ca 2+ ) uniporter channel (mtCU) resides at the inner mitochondrial membrane and is required for Ca 2+ to enter the...
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GCaMP, a Family of Single-Fluorophore Genetically Encoded Calcium Indicators
AbstractSingle-fluorophore genetically encoded calcium indicators (GECIs), such as GCaMP, are widely used tools to investigate neuronal activity....
