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In vivo visualization of the i-motif DNA secondary structure in the Bombyx mori testis
BackgroundA large number of in vitro experiments have confirmed that DNA molecules can form i-motif advanced structure when multiple cytosines exist...
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Protein–Protein Interfaces as Druggable Targets: A Common Motif of the Pyridoxal-5′-Phosphate-Dependent Enzymes to Receive the Coenzyme from Its Producers
AbstractPyridoxal-5′-phosphate (PLP), a phosphorylated form of vitamin B6, acts as a coenzyme for numerous reactions, including those changed in...
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The RNA i-Motif in the Primordial RNA World
The primordial RNA world is a hypothetical era prior to the appearance of protein and DNA, when RNA molecules were the sole building blocks for early...
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Study of peripheral domains in structure–function of isocitrate lyase (ICL) from Pseudomonas aeruginosa
The capacity of Pseudomonas aeruginosa to assimilate nutrients is essential for niche colonization and contributes to its pathogenicity. Isocitrate...
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The transmembrane domain of Frey1 harbors a transplantable inhibitory motif for intramembrane proteases
Although aspartic intramembrane-cleaving proteases (I-CLIPs) are crucial switches of multiple signaling pathways and involved in several devastating...
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Genome-wide association study unravels genomic regions associated with chlorophyll fluorescence parameters in wheat (Triticum aestivum L.) under different sowing conditions
Key messageGenome-wide association study identified 205 significant marker–trait associations for chlorophyll fluorescence parameters in wheat....
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Functional characterisation of Artemisia annua jasmonic acid carboxyl methyltransferase: a key enzyme enhancing artemisinin biosynthesis
Main conclusionOverexpression of Artemisia annua jasmonic acid carboxyl methyltransferase (AaJMT) leads to enhanced artemisinin content in Artemisia...
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Probable human origin of the SARS-CoV-2 polybasic furin cleavage motif
BackgroundThe key evolutionary step leading to the pandemic virus was the acquisition of the PRRA furin cleavage motif at the spike glycoprotein...
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Repurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV)
R-loop-triggered collateral single-stranded DNA (ssDNA) nuclease activity within Class 1 Type I CRISPR-Cas systems holds immense potential for...
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Indacaterol inhibits collective cell migration and IGDQ-mediated single cell migration in metastatic breast cancer MDA-MB-231 cells
Metastasis is the main cause of deaths related to breast cancer. This is particular the case for triple negative breast cancer. No targeted therapies...
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Genome-wide comparative analysis of the valine glutamine motif containing genes in four Ipomoea species
BackgroundGenes with valine glutamine (VQ) motifs play an essential role in plant growth, development, and resistance to biotic and abiotic stresses....
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iJAZ-based approach to engineer lepidopteran pest resistance in multiple crop species
The fall armyworm (FAW) poses a significant threat to global crop production. Here we showed that overexpression of jasmonate ZIM-domain (JAZ)...
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Reanalysis of a μ opioid receptor crystal structure reveals a covalent adduct with BU72
BackgroundThe first crystal structure of the active μ opioid receptor (μOR) exhibited several unexplained features. The ligand BU72 exhibited many...
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Probing Techniques of Secondary and Tertiary RNA Structure and a Case Study for RNA G-Quadruplexes
Like proteins, an RNA is only functional when it is folded into its native conformation and adopts a specific secondary and tertiary structure....
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Genome-wide identification and evolutionary analysis of the NRAMP gene family in the AC genomes of Brassica species
BackgroundBrassica napus , a hybrid resulting from the crossing of Brassica rapa and Brassica oleracea , is one of the most important oil crops....
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Genome-wide identification, structural homology analysis, and evolutionary diversification of the phospholipase D gene family in the venom gland of three scorpion species
BackgroundVenom phospholipase D (PLDs), dermonecrotic toxins like, are the major molecules in the crude venom of scorpions, which are mainly...
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An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking
β-Coronaviruses such as SARS-CoV-2 hijack coatomer protein-I (COPI) for spike protein retrograde trafficking to the progeny assembly site in...
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Identification and characterization of a new HNH restriction endonuclease with unusual properties
AbstractRestriction–modification (R-M) systems form a large superfamily constituting bacterial innate immunity mechanism. The restriction...
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Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome
BackgroundGrowing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome (DS). This work...
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MCM8-mediated mitophagy protects vascular health in response to nitric oxide signaling in a mouse model of Kawasaki disease
Mitophagy is a major quality control pathway that removes unwanted or dysfunctional mitochondria and plays an essential role in vascular health. Here...
