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Are Altered Expression of Vascular Endothelial Growth Factor and Placental Growth Factor Associated with Placental Angiogenesis in Recurrent Pregnancy Loss?
Angiogenesis is one of the most important steps during pregnancy for placental and fetal development. Based on the hypothesis that vascular...
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NUAK1 coordinates growth factor-dependent activation of mTORC2 and Akt signaling
BackgroundmTORC2 is a critical regulator of cytoskeleton organization, cell proliferation, and cancer cell survival. Activated mTORC2 induces maximal...
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Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes
BackgroundOptimal size at birth dictates perinatal survival and long-term risk of develo** common disorders such as obesity, type 2 diabetes and...
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Biology and therapeutic targeting of vascular endothelial growth factor A
The formation of new blood vessels, called angiogenesis, is an essential pathophysiological process in which several families of regulators have been...
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Circadian patterns of growth factor receptor-dependent signaling and implications for carcinogenesis
Several different signaling pathways that regulate cell proliferation and differentiation are initiated by binding of ligands to cell-surface and...
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Fibroblast growth factor signaling in axons: from development to disease
The fibroblast growth factor (FGF) family regulates various and important aspects of nervous system development, ranging from the well-established...
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Investigating Epidermal Growth Factor Receptor Trafficking with High-Resolution Enzymatic Protein-Tagging and Transmission Electron Microscopy
Enzymatic ascorbate peroxidase (APEX) tagging allows for high-resolution, three-dimensional protein distribution analyses in cells and tissues. This...
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Transforming Growth Factor-β1 in Cancer Immunology: Opportunities for Immunotherapy
Transforming growth factor-beta1 (TGF-β)TGF-β regulates a plethora of cell-intrinsic processes that modulate tumor progression in a context-dependent...
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A continuous myofibroblast precursor cell line from the tail muscle of Australasian snapper (Chrysophrys auratus) that responds to transforming growth factor beta and fibroblast growth factor
Chrysophrys auratus (Australasian snapper) is one of the largest and most valuable finfish from capture fisheries in New Zealand, yet no cell lines...
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Non-alcoholic fatty liver disease promotes breast cancer progression through upregulated hepatic fibroblast growth factor 21
Non-alcoholic fatty liver disease (NAFLD) has been shown to influence breast cancer progression, but the underlying mechanisms remain unclear. In...
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Fibroblast Growth Factor 23 Bone Regulation and Downstream Hormonal Activity
Mineral homeostasis of calcium and phosphate levels is one critical component to the maintenance of bone mineral density (BMD) and strength. Diseases...
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Targeting nerve growth factor-mediated osteosarcoma metastasis: mechanistic insights and therapeutic opportunities using larotrectinib
Osteosarcoma (OS) therapy presents numerous challenges, due largely to a low survival rate following metastasis onset. Nerve growth factor (NGF) has...
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Basic Fibroblast Growth Factor Accumulation in Culture Medium Masks the Direct Antitumor Effect of Anti-VEGF Agent Bevacizumab
AbstractThe direct antitumor effect of bevacizumab (BEV) has long been debated. Evidence of the direct antitumor activities of drugs are mainly...
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Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor
The bone marrow contains peripheral nerves that promote haematopoietic regeneration after irradiation or chemotherapy (myeloablation), but little is...
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Growth rate is a dominant factor predicting the rhizosphere effect
The root microbiome is shaped by plant root activity, which selects specific microbial taxa from the surrounding soil. This influence on the...
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FGFR1Pred: an artificial intelligence-based model for predicting fibroblast growth factor receptor 1 inhibitor
Fibroblast growth factor receptors (FGFRs) are a family of cell surface receptors that bind to fibroblast growth factor (FGF) and mediate various...
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Genome-wide identification and analysis of the growth-regulating factor (GRF) family in sweet cherry
Growth-regulating factor (GRF) proteins are vital in regulating plant growth, development, and abiotic stress response. However, little information...
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Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection
Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced...
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The Expression of Recombinant Human Hepatocyte Growth Factor in Pichia pastoris
AbstractThe aim of this study was to construct a stable and efficient eukaryotic expression system for the secretion of biologically active...
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Production of biologically active human basic fibroblast growth factor (hFGFb) using Nicotiana tabacum transplastomic plants
Main conclusionWe generated transplastomic tobacco lines that stably express a human Basic Fibroblast Growth Factor (hFGFb) in their chloroplasts...
