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Splicing complexity as a pivotal feature of alternative exons in mammalian species
BackgroundAs a significant process of post-transcriptional gene expression regulation in eukaryotic cells, alternative splicing (AS) of exons greatly...
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Exons 45–55 Skip** Using Antisense Oligonucleotides in Immortalized Human DMD Muscle Cells
Antisense oligonucleotides (AOs) have demonstrated high potential as a therapy for treating genetic diseases like Duchene muscular dystrophy (DMD)....
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Unraveling the role of **st in X chromosome inactivation: insights from rabbit model and deletion analysis of exons and repeat A
X chromosome inactivation (XCI) is a process that equalizes the expression of X-linked genes between males and females. It relies on **st ,...
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Knockout of circRNAs by base editing back-splice sites of circularized exons
Many circular RNAs (circRNAs) are produced from back-splicing of exons of precursor mRNAs and are generally co-expressed with cognate linear RNAs....
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NSD1 gene evolves under episodic selection within primates and mutations of specific exons in humans cause Sotos syndrome
BackgroundModern human brains and skull shapes differ from other hominids. Brain growth disorders as micro- (ASPM, MCPH1) and macrocephaly (NFIX,...
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Comprehensive analysis of genomic complexity in the 5’ end coding region of the DMD gene in patients of exons 1–2 duplications based on long-read sequencing
BackgroundDystrophinopathies are the most common X-linked inherited muscle diseases, and the disease-causing gene is DMD . Exonic duplications are a...
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Early Divergence of the C-Terminal Variable Region of Troponin T Via a Pair of Mutually Exclusive Alternatively Spliced Exons Followed by a Selective Fixation in Vertebrate Heart
Troponin T (TnT) is the thin filament anchoring subunit of troponin complex and plays an organizer role in the Ca 2+ -regulation of striated muscle...
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Novel alternatively-spliced exons of the VRK2 gene in mouse brain and microglial cells
Common sequence variations in the VRK2 gene contribute to genetic risk for various psychiatric diseases including schizophrenia and major depressive...
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Transcriptomic analysis reveals differential gene expression, alternative splicing, and novel exons during mouse trophoblast stem cell differentiation
BackgroundDifferentiation of mouse trophoblast stem cells (TSCs) to trophoblast giant cells (TGCs) has been widely used as a model system to study...
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Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skip** exons to reinitiate transcription and translation
BackgroundGene disruption in mouse embryonic stem cells or zygotes is a conventional genetics approach to identify gene function in vivo. However,...
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Base-Editor-Mediated circRNA Knockout by Targeting Predominantly Back-Splice Sites
Back-splicing of eukaryotic exon(s) leads to the production of covalently closed circular RNAs (circRNAs). Generally, most circRNAs contain...
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Regulation of micro- and small-exon retention and other splicing processes by GRP20 for flower development
Pre-mRNA splicing is crucial for gene expression and depends on the spliceosome and splicing factors. Plant exons have an average size of ~180...
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Study of glutathione S-transferase (CqGSTs) gene expression patterns, the response of basic helix–loop–helix (bHLH) transcription factor and genome-wide identification gene family in quinoa (Chenopodium quinoa Willd.) and its mechanisms of salt stress tolerance
Quinoa grains are nutritionally rich and balanced, rich in protein, starch, VB1, folic acid, minerals (Ca, Zn, Fe) and other nutrients and grow at...
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Gene Expression in Eukaryotes
Eukaryotes are multicellular organisms and thus have a complex process of gene regulation. In eukaryotes, the gene sequences are not continuous to...
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Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons
BackgroundOlfactory receptor (OR) genes are the largest multi-gene family in the mammalian genome, with 874 in human and 1483 loci in mouse...
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Alternative splicing coupled to nonsense-mediated decay coordinates downregulation of non-neuronal genes in develo** mouse neurons
BackgroundThe functional coupling between alternative pre-mRNA splicing (AS) and the mRNA quality control mechanism called nonsense-mediated decay...
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Coupling of co-transcriptional splicing and 3’ end Pol II pausing during termination in Arabidopsis
BackgroundIn Arabidopsis, RNA Polymerase II (Pol II) often pauses within a few hundred base pairs downstream of the polyadenylation site, reflecting...
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Evolution of Exons and the Exon–Intron Structure of Long Intergenic Noncoding RNA Genes in Placental Mammals
AbstractLong intergenic noncoding RNA (lincRNA) genes are abundant in mammals, but their functions remain elusive. The characteristics of lincRNAs...
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Potentials of single nucleotide polymorphisms and genetic diversity studies at HSP90AB1 gene in Nigerian White Fulani, Muturu, and N’Dama cattle breeds
The study was aimed at genetic characterization of Nigerian breeds of Muturu, N’Dama, and White Fulani cattle breeds at heat shock protein 90AB1...
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Evidence for widespread existence of functional novel and non-canonical human transcripts
BackgroundFraction of functional sequence in the human genome remains a key unresolved question in Biology and the subject of vigorous debate. While...
