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Desmin Degradation in Skeletal Muscles of Patients with Chronic Critical Illness
AbstractPatients with chronic critical illness lose a considerable portion of their muscle mass while hospitalized in an intensive care unit, which...
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Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?
BackgroundCritical illness is hallmarked by severe stress and organ damage. Fibroblast growth factor 21 (FGF21) has been shown to rise during...
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Structural and Metabolic Changes in Skeletal Muscles of Patients with Chronic Disorders of Consciousness—To the Issue of Critical Illness Polyneuromyopathies (a PET/CT Pathomorphological Study)
AbstractChronic disorders of consciousness (DOC) leads to the development of skeletal muscles dysfunction (weakness, pareses)—critical...
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Extracellular Matrix Alterations in Human Soleus Muscle under Conditions of Chronic Disorder of Consciousness
AbstractCritical illness myopathy (CIM) is a primary myopathy that develops in critically ill patients. Histological features of CIM include a...
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Epithelial Stem Cell Regeneration in Acute and Chronic Airway Injury
Airway epithelial stem cells are critical to maintaining airway homeostasis, especially after injury and illness. The loss of intact epithelium in... -
Epithelial Stem Cell Regeneration in Acute and Chronic Airway Injury
Airway epithelial stem cells are critical to maintaining airway homeostasis, especially after injury and illness. The loss of intact epithelium in... -
Genetically Modified Mesenchymal Stromal/Stem Cells: Application in Critical Illness
Critical illnesses including sepsis, acute respiratory distress syndromes, ischemic cardiovascular disorders and acute organ injuries are associated...
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Healthy lifestyle and life expectancy free of major chronic diseases at age 40 in China
Whether a healthy lifestyle helps achieve gains in life expectancy (LE) free of major non-communicable diseases and its share of total LE in Chinese...
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Ferroptosis and pyroptosis signatures in critical COVID-19 patients
Critical COVID-19 patients admitted to the intensive care unit (ICU) frequently suffer from severe multiple organ dysfunction with underlying...
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Synergistic effects of COVID-19 and Pseudomonas aeruginosa in chronic obstructive pulmonary disease: a polymicrobial perspective
This article discusses the connection between the novel coronavirus disease 2019 (COVID-19) caused by the coronavirus-2 (SARS-CoV-2) and chronic...
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Was Chagas disease responsible for Darwin’s illness? The overlooked eco-epidemiological context in Chile
The source of Darwin’s illness has been a contentious issue in the literature for almost 70 years. Different causal factors have been invoked to...
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A Critical Review of Current Worldwide Definitions of Sarcopenia
With the increasing number of elderly individuals worldwide, the prevalence of age-related loss of muscle mass, referred to as sarcopenia, is...
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Long-term follow-up and exploration of the mechanism of stromal vascular fraction gel in chronic wounds
BackgroundChronic refractory wounds easily relapse and seriously affect the patients’ quality of life. Previous studies have shown that stromal...
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Are Adiponectin and Insulin Resistance Related to Stress Hyperglycaemia in Critically Ill Patients?
Stress hyperglycaemia (SH) is frequent in critical illness, increases morbidity and mortality and is strongly associated with acute kidney injury...
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Nutraceuticals and Nanonutraceuticals Formulation for Chronic Disease – Cancer
Nutraceuticals are extensively explored for management of various types of cancer. They are generally regarded to be neutral and safe and are widely... -
Disrupting links between poverty, chronic stress, and educational inequality
The income-achievement gap is a significant and stubborn problem in the United States, which has been exacerbated by the Covid-19 pandemic. In this...
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The destruction of mucosal barriers, epithelial remodeling, and impaired mucociliary clearance: possible pathogenic mechanisms of Pseudomonas aeruginosa and Staphylococcus aureus in chronic rhinosinusitis
Chronic rhinosinusitis (CRS) is a pathological condition characterized by persistent inflammation in the upper respiratory tract and paranasal...
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Evaluation of the Crosstalk Between the Host Mycobiome and Bacteriome in Patients with Chronic Pancreatitis
The human microbiome is a diverse consortium of microbial kingdoms that play pivotal roles in host health and diseases. We previously reported a...
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Study on Effects of Probiotics on Gut Microbiome and Clinical Course in Patients with Critical Care Illnesses
Ventilator-associated pneumonia (VAP) is a nosocomial infection contracted by ventilator patients in which bacteria colonize the upper digestive...
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CD147 Plasma Levels in Hospitalised Patients with Covid-19 Pneumonia Predict Illness Severity and In-Hospital Mortality
COVID-19 and infectious diseases have been included in strategic development goals (SDG) of United Nations (UN). The CD147 receptor is one of several...