Search
Search Results
-
Biosynthesis of Novel Naphthoquinone Derivatives in the Commonly-used Chassis Cells Saccharomyces cerevisiae and Escherichia coli
Naphthoquinones harboring 1,4-naphthoquinone pharmacophore are considered as privileged structures in medicinal chemistry. In pharmaceutical industry...
-
Thermophilic cyanobacteria—exciting, yet challenging biotechnological chassis
AbstractThermophilic cyanobacteria are prokaryotic photoautotrophic microorganisms capable of growth between 45 and 73 °C. They are typically found...
-
Microbial chassis design and engineering for production of amino acids used in food industry
Rational microbial chassis design and engineering for improving production of amino acids have attracted a considerable attention. l -glutamate, l -lysi...
-
OPENPichia: licence-free Komagataella phaffii chassis strains and toolkit for protein expression
The industrial yeast Komagataella phaffii (formerly named Pichia pastoris ) is commonly used to synthesize recombinant proteins, many of which are...
-
Halomonas spp., as chassis for low-cost production of chemicals
AbstractHalomonas spp. are the well-studied platform organisms or chassis for next-generation industrial biotechnology (NGIB) due to their...
-
Nepeta cataria L. (catnip) can serve as a chassis for the engineering of secondary metabolic pathways
ObjectiveEvaluation of Nepeta cataria as a host with specific endogenous metabolite background for transient expression and metabolic engineering of...
-
Functional surface expression of immunoglobulin cleavage systems in a candidate Mycoplasma vaccine chassis
The Mycoplasma Immunoglobulin Binding/Protease (MIB-MIP) system is a candidate ‘virulence factor present in multiple pathogenic species of the Mollicutes...
-
Towards next-generation model microorganism chassis for biomanufacturing
AbstractSynthetic biology provides powerful tools and novel strategies for designing and modifying microorganisms to function as cell factories for...
-
Genome-Scale Metabolic Modeling of Escherichia coli and Its Chassis Design for Synthetic Biology Applications
Genome-scale metabolic modeling is and will continue to play a central role in computational systems metabolic engineering and synthetic biology...
-
Microbial chassis as the platform for production of dihydroxy xanthophyll-based carotenoids: an overview of recent advances in biomanufacturing
Physiological and environmental cues prompt microbes to synthesize diverse carotenoids, including dihydroxy xanthophylls, facilitating their...
-
Live Cells as Biosensors
The biosensors are seemed as a potential device to monitor and hit upon ecological pollutants, contaminants, and, more commonly, chemical or organic...
-
Biotech Meat: Growing Meat from Cells
This chapter shows how the latest advances in biotechnology are being used to create a new generation of meat alternatives, including cultured animal...
-
Stepwise genetic modification for efficient expression of heterologous proteins in Aspergillus nidulans
AbstractFilamentous fungi are widely used in food fermentation and therapeutic protein production due to their prominent protein secretion and...
-
Recent advances in single-cell engineered live biotherapeutic products research for skin repair and disease treatment
The human microbiome has emerged as a key player in maintaining skin health, and dysbiosis has been linked to various skin disorders. Amidst growing...
-
The current situations and limitations of genetic engineering in cyanobacteria: a mini review
Cyanobacteria are an ancient group of photoautotrophic prokaryotes, and play an essential role in the global carbon cycle. They are also model...
-
Identification of acidic stress-responsive genes and acid tolerance engineering in Synechococcus elongatus PCC 7942
AbstractCyanobacteria are excellent autotrophic photosynthetic chassis employed in synthetic biology, and previous studies have suggested that they...
-
Synthesis of pinene in the industrial strain Candida glycerinogenes by modification of its mevalonate pathway
Terpenes have many applications and are widely found in nature, but recent progress in synthetic biology has enabled the use of microorganisms as...
-
Advanced probiotics: bioengineering and their therapeutic application
The role of gut bacteria in human health has long been acknowledged and dysbiosis of the gut microbiota has been correlated with a variety of...
-
An oxidoreductase gene CtnD involved in citrinin biosynthesis in Monascus purpureus verified by CRISPR/Cas9 gene editing and overexpression
Monascus produces a kind of mycotoxin, citrinin, whose synthetic pathway is still not entirely clear. The function of CtnD , a putative oxidoreductase...
-
Multiplex gene knockout raises Ala-Gln production by Escherichia coli expressing amino acid ester acyltransferase
AbstractL-Alanyl-L-Glutamine (Ala-Gln) is a common parenteral nutritional supplement. In our previous study, the recombinant whole-cell catalyst Esche...
