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The origin of ovarian Leydig cells: a possibly solved enigma?
Over the years, the origin of ovarian Leydig cells has been, and still is, a topic subject to deep debate. Seven years ago, we proposed that this...
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Origin recognition complex 6 overexpression promotes growth of glioma cells
The discovery of novel oncotargets for glioma is of immense significance. We here explored the expression patterns, biological functions, and...
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Cancer Stem Cells are Actually Stem Cells with Disordered Differentiation: the Monophyletic Origin of Cancer
Cancer stem cells (CSCs) play an important role in cancer development. Based on advancements in CSC research, we propose a monophyletic model of...
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Syncytia: Origin, Structure, and Functions
This book gives a current overview on the development, origin, structure, and functions of germline and somatic cell syncytia during embryogenesis...
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The Ancient Origin and Function of Germline Cysts
Gamete production in most animal species is initiated within an evolutionarily ancient multicellular germline structure, the germline cyst, whose...
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Mesenchymal stromal cell-associated migrasomes: a new source of chemoattractant for cells of hematopoietic origin
BackgroundMultipotent mesenchymal stromal cells (MSCs) are precursors of various cell types. Through soluble factors, direct cell–cell interactions...
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Therapeutic Potential of Skin Stem Cells and Cells of Skin Origin: Effects of Botanical Drugs Derived from Traditional Medicine
Skin, the largest organ of the body, plays a vital role in protecting inner organs. Skin stem cells (SSCs) comprise a group of cells responsible for...
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Origin of Life and Glycan
The origin of life is dependent on biodiversity, which is the pathway of evolution. Organism evolution is intricately connected with glycan...
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Origin, Phenotype, and Function of Mouse Dendritic Cell Subsets
Dendritic cells are cells of hematopoietic origin that are specialized in antigen presentation and instruction of innate and adaptive immune...
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Current Views on Perineurial Cells: Unique Origin, Structure, Functions
AbstractThis review aims to consolidate current views on the cells of one of the peripheral nerve sheath layers, perineurium. The relevance of the...
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Differentiation of Hepatic Stellate Cells from Pluripotent Stem Cells
Hepatic stellate cells (HSCs) are non-parenchymal cells with a mesenchymal origin involved in vitamin A storage and extracellular matrix (ECM)...
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The Role of Endoplasmic Reticulum Stress in Differentiation of Cells of Mesenchymal Origin
AbstractEndoplasmic reticulum (ER) is a multifunctional membrane-enclosed organelle. One of the major ER functions is cotranslational transport and...
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Generation of Embryonic Origin-Specific Vascular Smooth Muscle Cells from Human Induced Pluripotent Stem Cells
Vascular smooth muscle cells (VSMCs), a highly mosaic tissue, arise from multiple distinct embryonic origins and populate different regions of our...
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The Origin of Eukaryotic Cells and Multicellular Organisms
First signs of life on EarthEarth were most probably in the form of unicellular organisms that rapidly diverged into different types while adapting...
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Restoring β Cells Population Through In Situ Differentiation of Residential Pancreatic Cells
Diabetes mellitus (DM) is a global health problem leading to morbidity, mortality, and compromising the quality of life. DM is well characterized by...
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The Role of the Integrated Response of Tumor Cells to Stress, Autophagy, and Chaperones in the Origin of Recurrent Resistant Tumors
AbstractChemotherapy and radiotherapy are colossal stress factors for tumor cells. In response to therapy, the entire evolutionarily fixed response...
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History, Origin, and Geographical Distribution of Subterranean Crops
The chapter extensively discusses the details pertaining to origin, history and geographical distribution of key subterranean crops.
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Ascidian embryonic cells with properties of neural-crest cells and neuromesodermal progenitors of vertebrates
Neural-crest cells and neuromesodermal progenitors (NMPs) are multipotent cells that are important for development of vertebrate embryos. In embryos...
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Syncytia in Utricularia: Origin and Structure
In animals and plants, multinucleate cells (syncytia and coenocytes) are essential in ontogeny and reproduction. Fuso-morphogenesis is the formation...