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Pparα activation stimulates autophagic flux through lipid catabolism-independent route
Autophagy is a cellular process that involves the fusion of autophagosomes and lysosomes to degrade damaged proteins or organelles. Triglycerides are...
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Catabolism and Its Coupling to Anabolism
The hundreds of simultaneously occurring biochemcial reactions in a microbial cell are ordered into catabolic and anabolic pathways based on their...
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Catabolism of 2-keto-3-deoxy-galactonate and the production of its enantiomers
Abstract2-Keto-3-deoxy-galactonate (KDGal) serves as a pivotal metabolic intermediate within both the fungal d -galacturonate pathway, which is...
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Impaired BCAA catabolism in adipose tissues promotes age-associated metabolic derangement
Adipose tissues are central in controlling metabolic homeostasis and failure in their preservation is associated with age-related metabolic...
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Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer
Availability of the essential amino acid methionine affects cellular metabolism and growth, and dietary methionine restriction has been implicated as...
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Glucosylglycerol phosphorylase, a potential novel pathway of microbial glucosylglycerol catabolism
AbstractGlucosylglycerol (GG) is a natural compatible solute that can be synthesized by many cyanobacteria and a few heterotrophic bacteria under...
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The Fe–S cluster assembly protein IscU2 increases α-ketoglutarate catabolism and DNA 5mC to promote tumor growth
IscU2 is a scaffold protein that is critical for the assembly of iron–sulfur (Fe–S) clusters and the functions of Fe–S-containing mitochondrial...
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Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis
BackgroundPeriostin is an extracellular matrix protein that plays a critical role in cell fate determination and tissue remodeling, but the...
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Prototypic Reactions, Modules, and Pathways of C1 catabolism
Anaerobic microbes catabolizing CO2 and C1 compounds represent the earliest forms of (microbial) Life on Earth. Microbial catabolism of C1 compounds...
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Bacterial Sialic Acid Catabolism at the Host–Microbe Interface
Sialic acids consist of nine-carbon keto sugars that are commonly found at the terminal end of mucins. This positional feature of sialic acids...
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Novel aspects of ethylene glycol catabolism
AbstractEthylene glycol (EG) is an industrially important two-carbon diol used as a solvent, antifreeze agent, and building block of polymers such as...
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Catabolism of strigolactones by a carboxylesterase
Strigolactones (SLs) are carotenoid-derived plant hormones that control shoot branching and communications between host plants and symbiotic fungi or...
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Prototypic Reactions of Prokaryotic Carbon Catabolism
Metabolic pathways are mosaics of a limited set of prototypic reactions occurring in a sequence that is based on structural features of a substrate...
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Serine catabolism generates liver NADPH and supports hepatic lipogenesis
Carbohydrate can be converted into fat by de novo lipogenesis, a process upregulated in fatty liver disease. Chemically, de novo lipogenesis involves...
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Fruit residues as substrates for single-cell oil production by Rhodococcus species: physiology and genomics of carbohydrate catabolism
Strains belonging to R. opacus , R. jostii , R. fascians , R. erythropolis and R. equi exhibited differential ability to grow and produce lipids from...
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Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism
Obesity, dyslipidemia and gut dysbiosis are all linked to cardiovascular diseases. A Ganoderma meroterpene derivative (GMD) has been shown to...
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Deciphering the transcriptional regulation of the catabolism of lignin-derived aromatics in Rhodococcus opacus PD630
Rhodococcus opacus PD630 has considerable potential as a platform for valorizing lignin due to its innate “biological funneling” pathways. However,...
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Genome-scale metabolic modeling reveals increased reliance on valine catabolism in clinical isolates of Klebsiella pneumoniae
Infections due to carbapenem-resistant Enterobacteriaceae have recently emerged as one of the most urgent threats to hospitalized patients within the...
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pparβ regulates lipid catabolism by mediating acox and cpt-1 genes in Scophthalmus maximus under heat stress
Peroxisome proliferator–activated receptor β ( pparβ ) is a key gene–regulating lipid metabolism pathway, but its function in turbot remains unclear....
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Heavy metals assessment of ecosystem polluted with wastewaters and taxonomic profiling of multi-resistant bacteria with potential for petroleum hydrocarbon catabolism in nitrogen-limiting medium
The coexistence of heavy metals (HMs) and petroleum hydrocarbons (PHs) exacerbates ecotoxicity and impair the drivers of eco-functionalities that...
