Abstract
The hundreds of simultaneously occurring biochemcial reactions in a microbial cell are ordered into catabolic and anabolic pathways based on their cellular functions. The fluxes of metabolites and intermediates between these major metabolic networks are coordinated and determine major traits of microbes. Natural selection shapes the allocation of the limited proteome space between catabolism and anabolism and can thereby explain physiological and metabolic features.
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Further Reading
Basan M et al (2015) Overflow metabolism in Escherichia coli results from efficient proteome allocation. Nature 528:99–103
Hui S, Silverman JM, Chen SS, Erickson DW, Basan M, Wang J, Hwa T, Williamson JR (2015) Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria. Mol Syst Biol 11:e784
Li GW, Burkhardt D, Gross C, Weissman JS (2014) Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources. Cell 157:624–635
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Spormann, A.M. (2023). Catabolism and Its Coupling to Anabolism. In: Principles of Microbial Metabolism and Metabolic Ecology. Springer, Cham. https://doi.org/10.1007/978-3-031-28218-8_4
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DOI: https://doi.org/10.1007/978-3-031-28218-8_4
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Publisher Name: Springer, Cham
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Online ISBN: 978-3-031-28218-8
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