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Stem Cell for Cartilage Repair
Several of the age-related joint diseases such as osteoarthritis lead to chondrocyte degeneration and loss of articular cartilage. Chondrocyte after...
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Stem Cell for Cartilage Repair
Several of the age-related joint diseases such as osteoarthritis lead to chondrocyte degeneration and loss of articular cartilage. Chondrocyte after...
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Cartilage Tissue Engineering
This detailed book brings together a collection of methodologies, from the most basic to the more complex, that provides researchers with a platform...
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Single-Cell Analysis Approaches in Cartilage Diseases Diagnosis and Therapies
Substantial evidence shows that major breakthrough toward cartilage therapeutic approaches is largely hampered by the low chondrocytes yield along...
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Single-cell RNA sequencing reveals differences between force application and bearing in ankle cartilage
AbstractChondrocytes are the major functional elements of articular cartilage. Force has been demonstrated to influence the structure and function of...
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Modeling early changes associated with cartilage trauma using human-cell-laden hydrogel cartilage models
BackgroundTraumatic impacts to the articular joint surface are known to lead to cartilage degeneration, as in post-traumatic osteoarthritis (PTOA)....
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Cell Therapy as a Novel Therapeutic Approach for Cartilage Diseases
Autologous Chondrocyte Implantation (ACI) has long been considered the gold standard for the repair of full-thickness articular cartilage defects,...
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Selenium Deficiency Can Promote the Expression of VEGF and Inflammatory Factors in Cartilage Differentiation and Mediates Cartilage Injury
Selenium plays a crucial role as a micronutrient, primarily exerting its biological functions through selenoproteins. It has been established that...
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Label-free, multi-parametric assessments of cell metabolism and matrix remodeling within human and early-stage murine osteoarthritic articular cartilage
Osteoarthritis (OA) is characterized by the progressive deterioration of articular cartilage, involving complicated cell-matrix interactions....
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Signaling Pathways Regulating Cartilage Formation
Over the course of many years of investigation, the molecular processes that regulate the differentiation of chondrocytes throughout the development...
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Low-intensity pulsed ultrasound promotes mesenchymal stem cell transplantation-based articular cartilage regeneration via inhibiting the TNF signaling pathway
BackgroundMesenchymal stem cell (MSC) transplantation therapy is highly investigated for the regenerative repair of cartilage defects. Low-intensity...
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Strategies to Control Mesenchymal Stem Cell Differentiation for Regenerating Phenotypically Defined Articular Cartilage
Articular cartilage has limited intrinsic ability for self-regeneration, and treatments to restore fully functional cartilage remain a challenge....
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Widely Used Biomaterials in Cartilage Biofabrication
Cartilage, a nonvascular type of supporting connective tissue, is a flexible tissue with a less organized microarchitecture than bone. Perichondrium...
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Advances in Hydrogels for Cartilage Regeneration
The main objective of cartilage tissue engineering is to introduce convenient engineered artificial matrices that can substitute the damaged areas...
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Defect-adaptive Stem-cell-microcarrier Construct Promotes Tissue Repair in Rabbits with Knee Cartilage Defects
Although various reconstruction techniques are available for cartilage defects, the repair effects and conveniences remain to be further improved due...
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Extracellular Vesicles: A Potent Therapeutic Tool for Cartilage Regeneration
Extracellular vesicles (EVs), which mostly include exosomes and microparticles are bilayer lipids that encapsulate nucleic acids and proteins. They...
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Isolation of Chondrons from Hyaline Cartilage
In native healthy hyaline cartilage, the chondrocytes are surrounded by a pericellular matrix that has a distinct composition and function compared...
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Cartilage Tissue Engineering: Advances and Frontiers
Defects in the cartilage caused by trauma, osteoarthritis, or other disorders invariably result in severe joint pain and dysfunction. Without access...
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Production and Application of Mesenchymal Stem Cell Spheroids for Cartilage and Bone Regeneration
Introduction: Cartilage and bone tissues are widely utilized in regenerative medicine, especially in treating injured cartilage and bone. Some...
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Extracellular Matrix Biomimicry for Cartilage Tissue Formation
Development of biomimetic constructs for cartilage tissue regeneration has become an increasing field of interest in today’s biomedical research....