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Polymorphisms of Growth Hormone and Calpastatin Genes and Their Association with Sheep Meat Quality
AbstractThe sheep breeeding for meat is of great interst at present due to rising meat intake among people. Over the recent decade, selective...
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Polymorphisms of Calpain and Calpastatin Cascade Genes in the Beef Cattle Population
AbstractOver the past decades, the selective breeding process has been accelerating with advances in molecular genetics and identification and...
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Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels
Melanoma represents the most serious type of skin cancer. Although recent years have seen advances using targeted and immunotherapies, most patients...
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Allelic and genotypic frequencies of SNP related to beef and carcass quality in Romosinuano cattle in Mexico
Romosinuano is a tropically adapted Bos taurus breed, and some Mexican breeders aim to improve it genetically. The aim was to estimate allelic and...
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Immunoblotting for Calpastatin Expression
Immunoblotting is a procedure routinely used to analyze calpastatin expression. However, immunoblotting alone may not be adequate for this task,...
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Isolation of Endogenous Calpastatin
We here describe the purification of calpastatin from human erythrocytes. When calpastatin is purified from tissues, it is necessary to measure its...
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Production and Purification of Recombinant Calpastatin
The production of recombinant calpastatin in E. coli has become an efficient tool to obtain discrete amounts of a specific calpastatin species that...
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Inhibition of calpain reduces cell apoptosis by suppressing mitochondrial fission in acute viral myocarditis
Cardiomyocyte apoptosis is critical for the development of viral myocarditis (VMC), which is one of the leading causes of cardiac sudden death in...
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Single-Step Purification of Calpain-1, Calpain-2, and Calpastatin Using Anion-Exchange Chromatography
Purification and separation of calpains and calpastatin are used to determine the individual activities of calpain-1 and calpain-2 and their...
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Calpain Purification Through Calpastatin and Calcium: Strategy and Procedures
This chapter describes the strategy and procedures for the calcium-mediated affinity purification of calpain. The affinity capture method exploits...
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Association of single nucleotide polymorphisms in the CAPN, CAST, LEP, GH, and IGF-1 genes with growth parameters and ultrasound characteristics of the Longissimus dorsi muscle in Colombian hair sheep
Recognition of the genes that influence livestock production characteristics has allowed researchers to identify single nucleotide polymorphisms...
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Sympathetic innervation in skeletal muscle and its role at the neuromuscular junction
Neuromuscular junctions are the synapses between motor neurons and skeletal muscle fibers, which mediate voluntary muscle movement. Since...
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Enzymes in the production of cultivated meat products
Enzymes play a pivotal role in meat processing and maturation, starting with endogenous enzymes that catalyse a partial proteolysis in natural meat...
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Calpain system is altered in survival motor neuron-reduced cells from in vitro and in vivo spinal muscular atrophy models
Spinal muscular atrophy (SMA) is a severe neuromuscular disorder caused by loss of the survival motor neuron 1 ( SMN1 ) gene. SMA is characterized by...
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Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions
An unambiguous description of an experiment, and the subsequent biological observation, is vital for accurate data interpretation. Minimum...
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The ERG1a potassium channel increases basal intracellular calcium concentration and calpain activity in skeletal muscle cells
BackgroundSkeletal muscle atrophy is the net loss of muscle mass that results from an imbalance in protein synthesis and protein degradation. It...
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Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington’s disease
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder featured by abnormal movements, arising from the extensive neuronal...
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Intracellular cartilage oligomeric matrix protein augments breast cancer resistance to chemotherapy
Chemotherapy persists as the primary intervention for breast cancer, with chemoresistance posing the principal obstacle to successful treatment....
