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Maternal exposure to polystyrene nanoplastics alters fetal brain metabolism in mice
IntroductionPlastics used in everyday materials accumulate as waste in the environment and degrade over time. The impacts of the resulting...
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Oral d-ribose causes depressive-like behavior by altering glycerophospholipid metabolism via the gut-brain axis
Our previous work has shown that d -ribose (RIB)-induced depressive-like behaviors in mice. However, the relationship between variations in RIB levels...
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Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases
The importance of neuroglia in maintaining normal brain function under physiological and pathological conditions has been supported by growing...
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Frontal–temporal regional differences in brain energy metabolism and mitochondrial function using 31P MRS in older adults
Aging is a major risk for cognitive decline and transition to dementia. One well-known age-related change involves decreased brain efficiency and...
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Ceruloplasmin Deficiency Impaired Brain Iron Metabolism and Behavior in Mice
Iron accumulation is an important cause of various brain diseases. As a ferroxidase, ceruloplasmin (Cp) plays a key role in iron homeostasis and its...
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Set7/9 aggravates ischemic brain injury via enhancing glutamine metabolism in a blocking Sirt5 manner
The aberrant expression of methyltransferase Set7/9 plays a role in various diseases. However, the contribution of Set7/9 in ischemic stroke remains...
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Brain histone beta-hydroxybutyrylation couples metabolism with gene expression
Little is known about the impact of metabolic stimuli on brain tissue at a molecular level. The ketone body beta-hydroxybutyrate (BHB) can be a...
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Brain CoA and Acetyl CoA Metabolism in Mechanisms of Neurodegeneration
AbstractThe processes of biotransformation of pantothenic acid (Pan) in the biosynthesis and hydrolysis of CoA, key role of pantothenate kinase...
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The Role of C1473G Polymorphism in Mouse Triptophan Hydroxylase 2 Gene in the Acute Effects of Ethanol on the c-fos Gene Expression and Metabolism of Biogenic Amines in the Brain
AbstractTryptophan hydroxylase 2 is a key enzyme in the synthesis of the neurotransmitter serotonin, which plays an important role in the regulation...
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Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment
Exploring individual hallmarks of brain ageing is important. Here, we propose the age-related glucose metabolism pattern (ARGMP) as a potential index...
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Microglia and macrophage metabolism: a regulator of cerebral gliomas
Reciprocal interactions between the tumor microenvironment (TME) and cancer cells play important roles in tumorigenesis and progression of glioma....
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Circadian-independent light regulation of mammalian metabolism
The daily light–dark cycle is a key zeitgeber (time cue) for entraining an organism’s biological clock, whereby light sensing by retinal...
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SMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy
Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 ( SMN1 ) gene cause multiorgan and metabolic defects in patients...
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Mitigating gut microbial degradation of levodopa and enhancing brain dopamine: Implications in Parkinson’s disease
Parkinson’s disease is managed using levodopa; however, as Parkinson’s disease progresses, patients require increased doses of levodopa, which can...
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Lipid Metabolism
Lipids are a heterogeneous group of water-insoluble compounds that are soluble in organic solvents. Besides being an important constituent of the...
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Dysregulated lipid metabolism in TMZ-resistant glioblastoma: pathways, proteins, metabolites and therapeutic opportunities
Glioblastoma (GBM) is a highly aggressive and lethal brain tumor with limited treatment options, such as the chemotherapeutic agent, temozolomide...
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Nitrogen Metabolism
Nitrogen is one of the most important macronutrients required by plants. All proteins consist of nitrogen-containing amino acids. Heme components of...
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Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians
Oxidative stress is an important factor in age-associated neurodegeneration. Accordingly, mitochondrial dysfunction and genomic instability have been...
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Changes in the Metabolism of Sphingomyelin and Ceramide in the Brain Structures and Spinal Cord of Transgenic Mice (FUS(1-359)) Modeling Amyotrophic Lateral Sclerosis
AbstractChanges in the expression of genes for enzymes of sphingolipid metabolism in transgenic FUS mice (FUS (1-359)) simulating amyotrophic lateral...
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Sphingolipid Metabolism in Tumor Cells
AbstractSphingolipids are a diverse family of complex lipids typically composed of a sphingoid base bound to a fatty acid via amide bond. The...
