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Remarkable enhancement of bleomycin production through precise amplification of its biosynthetic gene cluster in Streptomyces verticillus
Amplification of biosynthetic gene clusters is important to increase secondary metabolite production. However, the copy number of amplified gene...
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Investigation of the mechanism of copy number variations involving the α-globin gene cluster on chromosome 16: two case reports and literature review
Thalassemia is one of the most common single-gene disorder worldwide. An important genetic cause of thalassemia is copy number variations (CNVs) in...
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The miR-183/96/182 cluster is upregulated in glioblastoma carrying EGFR amplification
Glioblastoma (GBM) is one of the most frequent primary brain tumors. Limited therapeutic options and high recurrency rates lead to a dismal...
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Nucleic Acid Amplification Free-QCM-DNA Biosensor for Burkholderia pseudomallei Detection
Burkholderia pseudomallei is a gram-negative bacterium that causes the infectious disease melioidosis, a disease that can still be fatal despite...
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Heterologous production of new lanthipeptides hazakensins A and B using a cryptic gene cluster of the thermophilic bacterium Thermosporothrix hazakensis
The thermophilic bacterium Thermosporothrix hazakensis belongs to a class of Ktedonobacteria in the phylum Chloroflexota . Lanthipeptides are a...
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Machine Learning-Driven Discovery of Quadruple-Negative Breast Cancer Subtypes from Gene Expression Data
Unraveling the intricacies of Quadruple-Negative Breast Cancer (QNBC), this study leverages advanced analytics on RNAseq gene expression data....
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MAF amplification licenses ERα through epigenetic remodelling to drive breast cancer metastasis
MAF amplification increases the risk of breast cancer (BCa) metastasis through mechanisms that are still poorly understood yet have important...
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Variability of the Tannase Gene from Extreme Environments Uncultivable Microorganisms
Tannase or tannin acyl hydrolase (EC. 3.1.120) has diverse potential applications in the food industry, because of this, it is necessary to count...
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Inheritance and molecular map** of solitary/cluster fruit-bearing habit in Luffa
Fruiting behaviour and sex form are important goals for Luffa breeders and this study aimed to shed light upon inheritance patterns for both these...
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Fine-map** and evolutionary history of R-BPMV, a dominant resistance gene to Bean pod mottle virus in Phaseolus vulgaris L.
Key messageR-BPMV is located within a recently expanded TNL cluster in the Phaseolus genus with suppressed recombination and known for resistance to...
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Identification of PKS Gene Clusters from Metagenomic Libraries Using a Next-Generation Sequencing Approach
Microbial secondary metabolites have been an important source of bioactive compounds with diverse applications from medicine to agriculture,...
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Expression study of microRNA cluster on chromosome 19 (C19MC) in tumor tissue and serum of breast cancer patient
BackgroundBreast cancer (BC) is the most prevalent cancer among females worldwide. Numerous studies suggest that specific RNAs play a crucial role in...
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Identification and Expression Pattern Analysis of the bZIP Gene Family Based on the Whole Genome of Rosa chinensis (Jacq.)
AbstractBasic leucine zipper (bZIP) transcription factors play a crucial role in both biotic and abiotic stress responses in plants, making them...
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Modeling of large-scale hoxbb cluster deletions in zebrafish uncovers a role for segmentation pathways in atrioventricular boundary specification
Hox genes orchestrate the segmental specification of the muscular circulatory system in invertebrates but it has not proven straightforward to...
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A cluster of putative resistance genes is associated with a dominant resistance to sunflower broomrape
Key messageThe HaOr5 resistance gene is located in a large genomic insertion containing putative resistance genes and provides resistance to O....
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Reliable detection of Burkholderia pseudomallei using multiple cross displacement amplification label-based biosensor
BackgroundBurkholderia pseudomallei ( B. pseudomallei ), as a highly pathogenic organism, causes melioidosis, which is a disease of public health...
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Holistic expression of miR-17-92 cluster in obesity, kidney diseases, cardiovascular diseases, and diabetes
miR-17-92 cluster encodes six micro RNAs (miRNAs) and plays a crucial role in the regulation of various cellular processes. Aberrant expression of...
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tRNA-Cys gene clusters exhibit high variability in Arabidopsis thaliana
Although most of the genes encoding tRNAs in plants are dispersed throughout the genome, a fraction of them form tRNA gene clusters. In Arabidopsis...
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CRISPR Gene Editing of Hematopoietic Stem and Progenitor Cells
Genetic editing of hematopoietic stem and progenitor cells can be employed to understand gene-function relationships underlying hematopoietic cell...
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Integrated multiomics analysis of chromosome 19 miRNA cluster in bladder cancer
With 46 microRNAs (miRNAs) embedded tandemly over a distance of ~100 kb, chromosome 19 microRNA cluster (C19MC) is the largest miRNA cluster in the...
