Search
Search Results
-
Promoting Oligodendrocyte Differentiation from Human Induced Pluripotent Stem Cells by Activating Endocannabinoid Signaling for Treating Spinal Cord Injury
Transplantation of oligodendrocyte progenitor cell (OPC) at the injury site is being developed as a potential therapeutic strategy for promoting...
-
Cellular Assay to Study β-Arrestin Recruitment by the Cannabinoid Receptors 1 and 2
Cannabinoid receptor 1 (CB1R) and cannabinoid receptor 2 (CB2R) are G protein-coupled receptors (GPCRs) that activate a variety of pathways upon...
-
The Analgesic Effects of Cannabis
Drugs derived from Cannabis were used until the 1940s for their stimulant and depressant effects in treating somatic and psychiatric illnesses....
-
A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo
Endocannabinoids (eCBs) are retrograde neuromodulators with important functions in a wide range of physiological processes, but their in vivo...
-
Cannabis and Cancer
The International Agency for Research on Cancer report on the global burden of cancer estimated 18.1 million new cancer cases (17.0 million excluding...
-
Endocannabinoid-Binding Receptors as Drug Targets
Cannabis plant has been used from ancient times with therapeutic purposes for treating human pathologies, but the identification of the cellular and...
-
Neurological Effects of Cannabis
Cannabis products and Cannabis use are inherently variable. Given the difficulty in standardizing Cannabis products and Cannabis use patterns,...
-
Balancing the Neuroprotective Versus Neurotoxic Effects of Cannabis
Cannabinoids are chemicals that can be endogenous, natural, and synthetic substances which has the ability to bind to the cannabinoid receptors and...
-
Cannabis and Perinatal Development
Evidence supports the endocannabinoid (eCB) system’s role in the central nervous system patterning in structures relevant to mood, cognition, and...
-
Evidence from the Use of Herbal Medicines in the Management and Prevention of Common Eye Diseases
The fact that botanical compounds have been extensively used to cure various diseases and ailments throughout history is well known. Several of these...
-
Evidence from the Use of Herbal Medicines in the Management and Prevention of Common Eye Diseases
The fact that botanical compounds have been extensively used to cure various diseases and ailments throughout history is well known. Several of these...
-
Psychotropic Effects of Cannabis
Brain development is a complex phenomenon from fetal life to adolescence. During this period, the brain’s maturation proceeds through a series of...
-
Cannabis and Multiple Sclerosis
Multiple sclerosis (MS) is a chronic demyelinating disease of the central and peripheral nervous systems. The symptoms, such as vision problems,...
-
Modulation of VGCCs by G-Protein Coupled Receptors and Their Second Messengers
Voltage-gated calcium channels (VGCCs) are essential for transforming electrical signals such as action potentials into biochemical and eventually...
-
Novel Fubinaca/Rimonabant hybrids as endocannabinoid system modulators
The discovery of novel modulators of the cannabinoid system is a current topic in medicinal chemistry. In this paper, we report nine novel...
-
Control of excessive neural circuit excitability and prevention of epileptic seizures by endocannabinoid signaling
Progress in research on endocannabinoid signaling has greatly advanced our understanding of how it controls neural circuit excitability in health and...
-
Control of glutamate release by complexes of adenosine and cannabinoid receptors
BackgroundIt has been hypothesized that heteromers of adenosine A 2A receptors (A2AR) and cannabinoid CB 1 receptors (CB1R) localized in glutamatergic...
-
Allosteric Sites and Allosteric Regulators of G Protein-Coupled Receptors: Gray Cardinals of Signal Transduction
AbstractMembrane G protein-coupled receptors (GPCRs) are key components of most eukaryotic signaling systems, transducing external signals to...
-
The Pharmacology and Therapeutic Potential of Plant Cannabinoids
The plant Cannabis sativa has been widely used by humans over many centuries as a source of fibre, for medicinal purposes, for religious ceremonies...
-
Endocannabinoid hydrolases in avian HD11 macrophages identified by chemoproteomics: inactivation by small-molecule inhibitors and pathogen-induced downregulation of their activity
The endocannabinoids (eCBs) are endogenous arachidonoyl-containing lipid mediators with important roles in host defense. Macrophages are first-line...
